Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAP4K1 | Q92918 | 1/20 | 0.62 |
| ▸ | PTK2 | Q05397 | 4/20 | 0.60 |
| ▸ | JAK2 | O60674 | 1/20 | 0.59 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.59 |
| ▸ | TYK2 | P29597 | 1/20 | 0.59 |
| ▸ | KDR | P35968 | 1/20 | 0.59 |
| ▸ | JAK3 | P52333 | 1/20 | 0.59 |
| ▸ | PTK2B | Q14289 | 1/20 | 0.59 |
| ▸ | NTRK3 | Q16288 | 1/20 | 0.59 |
| ▸ | NTRK2 | Q16620 | 1/20 | 0.59 |
| ▸ | LRRK2 | Q5S007 | 10/20 | 0.58 |
| ▸ | ALK | Q9UM73 | 4/20 | 0.57 |
| ▸ | INSR | P06213 | 2/20 | 0.57 |
| ▸ | IGF1R | P08069 | 2/20 | 0.57 |
| ▸ | MAPK3 | P27361 | 1/20 | 0.55 |
| ▸ | TTK | P33981 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30002125 | 1.00 | MAP4K1 (0.62) | MAP4K1PTK2JAK2NTRK1TYK2 | |
| SCHEMBL24752748 | 0.92 | MAPK3 (0.65) | MAP4K1PTK2JAK2NTRK1TYK2 | |
| SCHEMBL30001807 | 0.92 | MAPK3 (0.65) | MAP4K1PTK2JAK2NTRK1TYK2 | |
| SCHEMBL24752696 | 0.92 | MAP4K1 (0.63) | MAP4K1PTK2JAK2NTRK1TYK2 | |
| SCHEMBL30002933 | 0.92 | MAP4K1 (0.59) | MAP4K1PTK2JAK2NTRK1TYK2 | |
| SCHEMBL24752219 | 0.92 | MAP4K1 (0.59) | MAP4K1PTK2JAK2NTRK1TYK2 | |
| SCHEMBL30001769 | 0.88 | MAP4K1 (0.56) | MAP4K1PTK2JAK2NTRK1TYK2 | |
| SCHEMBL24752676 | 0.88 | MAP4K1 (0.56) | MAP4K1PTK2JAK2NTRK1TYK2 | |
| SCHEMBL28969623 | 0.88 | MAP4K1 (0.56) | MAP4K1PTK2JAK2NTRK1TYK2 | |
| SCHEMBL30001774 | 0.88 | MAP4K1 (0.56) | MAP4K1PTK2JAK2NTRK1TYK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-116870016-B | Heteroaromatic compound and medical application thereof | 希格生科（深圳）有限公司 | 2024-05-28 | — | — | CN | disclosed |
| CN-117412981-A | Phosphine oxide derivative and preparation method and application thereof | 希格生科（深圳）有限公司 | 2024-01-16 | — | — | CN | disclosed |
| CN-116870016-A | Heteroaromatic compound and medical application thereof | 希格生科（深圳）有限公司 | 2023-10-13 | — | — | CN | disclosed |
| CN-115785154-A | Heteroaromatic ring compounds and medical use thereof | 希格生科（深圳）有限公司 | 2023-03-14 | — | — | CN | disclosed |
| WO-2022253081-A1 | PHOSPHINE OXIDE DERIVATIVE, PREPARATION METHOD THEREFOR AND APPLICATION THEREOF | 希格生科（深圳）有限公司 | 2022-12-08 | — | — | WO | disclosed |