Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK2 | O60674 | 12/20 | 0.45 |
| ▸ | JAK3 | P52333 | 11/20 | 0.45 |
| ▸ | JAK1 | P23458 | 8/20 | 0.45 |
| ▸ | EPHX2 | P34913 | 3/20 | 0.32 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.32 |
| ▸ | DGAT1 | O75907 | 2/20 | 0.31 |
| ▸ | CA12 | O43570 | 2/20 | 0.31 |
| ▸ | CA1 | P00915 | 2/20 | 0.31 |
| ▸ | CA2 | P00918 | 2/20 | 0.31 |
| ▸ | CA4 | P22748 | 2/20 | 0.31 |
| ▸ | CA7 | P43166 | 2/20 | 0.31 |
| ▸ | CA9 | Q16790 | 2/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2475996 | 0.95 | JAK2 (0.51) | JAK2JAK3JAK1MAPK1 | |
| SCHEMBL2375766 | 0.95 | JAK2 (0.48) | JAK2JAK3JAK1EPHX2MAPK1 | |
| SCHEMBL2375773 | 0.95 | JAK2 (0.48) | JAK2JAK3JAK1EPHX2MAPK1 | |
| SCHEMBL2378224 | 0.94 | JAK2 (0.51) | JAK2JAK3JAK1EPHX2 | |
| SCHEMBL2378230 | 0.94 | JAK2 (0.51) | JAK2JAK3JAK1EPHX2 | |
| SCHEMBL2378232 | 0.94 | JAK2 (0.51) | JAK2JAK3JAK1EPHX2 | |
| SCHEMBL2376556 | 0.92 | JAK2 (0.55) | JAK2JAK3JAK1EPHX2 | |
| SCHEMBL2376567 | 0.92 | JAK2 (0.55) | JAK2JAK3JAK1EPHX2 | |
| SCHEMBL2377787 | 0.92 | JAK2 (0.55) | JAK2JAK3JAK1EPHX2 | |
| SCHEMBL2376805 | 0.91 | JAK2 (0.56) | JAK2JAK3JAK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2373653-A1 | PYRROLOPYRAZINYL UREA KINASE INHIBITORS | F. Hoffmann-La Roche AG (CH) | 2011-10-12 | — | — | EP | disclosed |
| WO-2010063634-A1 | PYRROLOPYRAZINYL UREA KINASE INHIBITORS | F. HOFFMANN-LA ROCHE AG (CH) | 2010-06-10 | — | — | WO | disclosed |