Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AXL | P30530 | 19/20 | 0.76 |
| ▸ | AURKB | Q96GD4 | 2/20 | 0.76 |
| ▸ | AURKA | O14965 | 1/20 | 0.76 |
| ▸ | NEK2 | P51955 | 1/20 | 0.60 |
| ▸ | JAK2 | O60674 | 1/20 | 0.53 |
| ▸ | IGF1R | P08069 | 1/20 | 0.53 |
| ▸ | ALK | Q9UM73 | 1/20 | 0.53 |
| ▸ | PTK2 | Q05397 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22872055 | 0.89 | AXL (0.80) | AXLAURKBAURKANEK2JAK2 | |
| Dubermatinib SCHEMBL29394359 | 0.86 | AXL (1.00) | AXLAURKBAURKANEK2JAK2 | |
| Dubermatinib SCHEMBL12813478 | 0.86 | AXL (1.00) | AXLAURKBAURKANEK2JAK2 | |
| SCHEMBL31173499 | 0.86 | AXL (0.83) | AXLAURKBAURKANEK2JAK2 | |
| SCHEMBL25837786 | 0.86 | AXL (0.83) | AXLAURKBAURKANEK2JAK2 | |
| SCHEMBL25837701 | 0.84 | AXL (0.83) | AXLAURKBAURKANEK2JAK2 | |
| Dubermatinib SCHEMBL30437663 | 0.82 | AXL (0.87) | AXLAURKBAURKANEK2PTK2 | |
| Dubermatinib SCHEMBL29814119 | 0.82 | AXL (0.87) | AXLAURKBAURKANEK2PTK2 | |
| Dubermatinib SCHEMBL29814405 | 0.82 | AXL (0.87) | AXLAURKBAURKANEK2PTK2 | |
| SCHEMBL31173516 | 0.81 | AXL (0.80) | AXLAURKBAURKANEK2JAK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20220356185-A1 | MERTK DEGRADERS AND USES THEREOF | KYMERA THERAPEUTICS, INC. | 2022-11-10 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20220356185-A1 | MERTK DEGRADERS AND USES THEREOF | MERTK, ITK, CRKL | AXL 55/4885AURKB 707/4885AURKA 305/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.