Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NTRK1 | P04629 | 2/20 | 0.68 |
| ▸ | CDK7 | P50613 | 12/20 | 0.54 |
| ▸ | FLT3 | P36888 | 5/20 | 0.52 |
| ▸ | KIT | P10721 | 2/20 | 0.52 |
| ▸ | FGFR1 | P11362 | 2/20 | 0.49 |
| ▸ | FGFR3 | P22607 | 2/20 | 0.49 |
| ▸ | FGFR2 | P21802 | 1/20 | 0.49 |
| ▸ | NTRK3 | Q16288 | 2/20 | 0.48 |
| ▸ | NTRK2 | Q16620 | 1/20 | 0.48 |
| ▸ | CDK2 | P24941 | 2/20 | 0.48 |
| ▸ | CDC7 | O00311 | 2/20 | 0.48 |
| ▸ | DAPK3 | O43293 | 2/20 | 0.48 |
| ▸ | ROCK2 | O75116 | 2/20 | 0.48 |
| ▸ | PRKD3 | O94806 | 2/20 | 0.48 |
| ▸ | MAP4K4 | O95819 | 2/20 | 0.48 |
| ▸ | PAK4 | O96013 | 2/20 | 0.48 |
| ▸ | PIM1 | P11309 | 2/20 | 0.48 |
| ▸ | PRKACA | P17612 | 2/20 | 0.48 |
| ▸ | CSNK1A1 | P48729 | 2/20 | 0.48 |
| ▸ | CLK2 | P49760 | 2/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2480608 | 0.90 | FLT3 (0.59) | NTRK1CDK7FLT3KITFGFR1 | |
| SCHEMBL2482107 | 0.90 | FLT3 (0.59) | NTRK1CDK7FLT3KITFGFR1 | |
| SCHEMBL1334968 | 0.89 | NTRK1 (0.69) | NTRK1CDK7FLT3KITFGFR1 | |
| SCHEMBL1335092 | 0.89 | NTRK1 (0.61) | NTRK1CDK7FLT3KITFGFR1 | |
| SCHEMBL1336232 | 0.86 | NTRK1 (0.65) | NTRK1CDK7FLT3KITCDK2 | |
| SCHEMBL1336378 | 0.85 | NTRK1 (0.57) | NTRK1FLT3KITCDK2IRAK4 | |
| SCHEMBL2482316 | 0.85 | FLT3 (0.58) | NTRK1CDK7FLT3KITFGFR1 | |
| SCHEMBL1336493 | 0.82 | NTRK1 (0.63) | NTRK1CDK7FLT3KITFGFR1 | |
| SCHEMBL1334169 | 0.82 | NTRK1 (1.00) | NTRK1FLT3KITFGFR1NTRK3 | |
| SCHEMBL1336555 | 0.81 | NTRK1 (0.82) | NTRK1FLT3KITNTRK3NTRK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2373626-A1 | SUBSTITUTED INDAZOLE DERIVATIVES ACTIVE AS KINASE INHIBITORS | Nerviano Medical Sciences S.r.l. (IT) | 2011-10-12 | — | — | EP | claimed |
| EP-2373626-A1 | SUBSTITUTED INDAZOLE DERIVATIVES ACTIVE AS KINASE INHIBITORS | Nerviano Medical Sciences S.r.l. (IT) | 2011-10-12 | — | — | EP | disclosed |