Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLQ | O75417 | 13/20 | 0.53 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.38 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29695033 | 0.89 | POLQ (0.50) | POLQKMT2APOLBSCN9A | |
| SCHEMBL24501117 | 0.89 | POLQ (0.50) | POLQKMT2APOLBSCN9A | |
| SCHEMBL25306864 | 0.89 | POLQ (0.63) | POLQ | |
| SCHEMBL30526637 | 0.89 | POLQ (0.63) | POLQ | |
| SCHEMBL24769589 | 0.88 | POLQ (0.67) | POLQNR1I2SCN9A | |
| SCHEMBL30018237 | 0.88 | POLQ (0.67) | POLQNR1I2SCN9A | |
| SCHEMBL22717386 | 0.84 | POLQ (0.48) | POLQKMT2ANR1I2 | |
| SCHEMBL30016931 | 0.84 | POLQ (0.48) | POLQKMT2ANR1I2 | |
| SCHEMBL29694827 | 0.84 | POLQ (0.48) | POLQKMT2ANR1I2 | |
| SCHEMBL24770127 | 0.81 | POLQ (0.53) | POLQKMT2APOLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4352055-A1 | O-LINKED THIADIAZOLYL COMPOUNDS AS DNA POLYMERASE THETA INHIBITORS | Ideaya Biosciences, Inc. (US) | 2024-04-17 | — | — | EP | disclosed |
| CN-117794927-A | O-linked thiadiazolyl compounds as inhibitors of DNA polymerase theta | 伊迪亚生物科学有限公司 | 2024-03-29 | — | — | CN | disclosed |
| WO-2022259204-A1 | O-LINKED THIADIAZOLYL COMPOUNDS AS DNA POLYMERASE THETA INHIBITORS | IDEAYA BIOSCIENCES, INC. (US) | 2022-12-15 | — | — | WO | disclosed |
| WO-2022259204-A1 | O-LINKED THIADIAZOLYL COMPOUNDS AS DNA POLYMERASE THETA INHIBITORS | IDEAYA BIOSCIENCES, INC. (US) | 2022-12-15 | — | — | WO | disclosed |