Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLQ | O75417 | 9/20 | 0.60 |
| ▸ | POLB | P06746 | 1/20 | 0.42 |
| ▸ | NR4A2 | P43354 | 2/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 2/20 | 0.40 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
| ▸ | TSHR | P16473 | 1/20 | 0.40 |
| ▸ | HTT | P42858 | 1/20 | 0.40 |
| ▸ | NR1H2 | P55055 | 1/20 | 0.39 |
| ▸ | NR1H3 | Q13133 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30018023 | 1.00 | POLQ (0.60) | POLQPOLBNR4A2ALDH1A1LMNA | |
| SCHEMBL30017668 | 0.91 | POLQ (0.65) | POLQLMNAGAA | |
| SCHEMBL30017235 | 0.91 | POLQ (0.53) | POLQPOLBALDH1A1KDM4E | |
| SCHEMBL24770127 | 0.91 | POLQ (0.53) | POLQPOLBALDH1A1KDM4E | |
| SCHEMBL24770154 | 0.91 | POLQ (0.65) | POLQLMNAGAA | |
| SCHEMBL24769589 | 0.86 | POLQ (0.67) | POLQALDH1A1LMNANPSR1KDM4E | |
| SCHEMBL30018237 | 0.86 | POLQ (0.67) | POLQALDH1A1LMNANPSR1KDM4E | |
| SCHEMBL24769533 | 0.84 | POLQ (0.55) | POLQALDH1A1NPSR1TSHR | |
| SCHEMBL30017598 | 0.84 | POLQ (0.55) | POLQALDH1A1NPSR1TSHR | |
| SCHEMBL30526837 | 0.83 | POLQ (0.53) | POLQNPSR1HTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-117794927-A | O-linked thiadiazolyl compounds as inhibitors of DNA polymerase theta | 伊迪亚生物科学有限公司 | 2024-03-29 | — | — | CN | disclosed |
| WO-2022259204-A1 | O-LINKED THIADIAZOLYL COMPOUNDS AS DNA POLYMERASE THETA INHIBITORS | IDEAYA BIOSCIENCES, INC. (US) | 2022-12-15 | — | — | WO | disclosed |