Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP3A4 | P08684 | 1/20 | 0.49 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.49 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.49 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.49 |
| ▸ | FGFR2 | P21802 | 1/20 | 0.49 |
| ▸ | FGFR4 | P22455 | 1/20 | 0.49 |
| ▸ | FGFR3 | P22607 | 1/20 | 0.49 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.49 |
| ▸ | ALOX5AP | P20292 | 2/20 | 0.39 |
| ▸ | FEN1 | P39748 | 2/20 | 0.39 |
| ▸ | EGFR | P00533 | 10/20 | 0.36 |
| ▸ | BTK | Q06187 | 4/20 | 0.36 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.34 |
| ▸ | JAK3 | P52333 | 4/20 | 0.34 |
| ▸ | ERBB2 | P04626 | 1/20 | 0.32 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.32 |
| ▸ | KDR | P35968 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24773303 | 0.86 | FGFR4 (0.58) | CYP3A4CYP2D6FGFR1CYP2C9FGFR2 | |
| SCHEMBL24772975 | 0.84 | CYP3A4 (0.52) | CYP3A4CYP2D6FGFR1CYP2C9FGFR2 | |
| SCHEMBL24772972 | 0.83 | FGFR4 (0.53) | CYP3A4CYP2D6FGFR1CYP2C9FGFR2 | |
| SCHEMBL24772963 | 0.82 | FGFR4 (0.52) | CYP3A4CYP2D6FGFR1CYP2C9FGFR2 | |
| SCHEMBL24772976 | 0.81 | CYP3A4 (0.49) | CYP3A4CYP2D6FGFR1CYP2C9FGFR2 | |
| SCHEMBL24772790 | 0.81 | FGFR4 (0.47) | CYP3A4CYP2D6FGFR1CYP2C9FGFR2 | |
| SCHEMBL24772782 | 0.81 | FGFR1 (0.48) | CYP3A4CYP2D6FGFR1CYP2C9FGFR2 | |
| SCHEMBL24773518 | 0.81 | CYP3A4 (0.48) | CYP3A4CYP2D6FGFR1CYP2C9FGFR2 | |
| SCHEMBL24772736 | 0.80 | FGFR4 (0.57) | CYP3A4CYP2D6FGFR1CYP2C9FGFR2 | |
| SCHEMBL24773305 | 0.79 | FGFR1 (0.47) | CYP3A4CYP2D6FGFR1CYP2C9FGFR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022206939-A1 | HETEROCYCLIC COMPOUND SERVING AS FGFR INHIBITOR AND APPLICATION THEREOF | 海南耀臻生物医药科技有限公司 | 2022-10-06 | — | — | WO | disclosed |