Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DDB1 | Q16531 | 1/20 | 0.55 |
| ▸ | CRBN | Q96SW2 | 1/20 | 0.55 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.48 |
| ▸ | HPGD | P15428 | 1/20 | 0.47 |
| ▸ | NR1H2 | P55055 | 1/20 | 0.44 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
| ▸ | USP30 | Q70CQ3 | 2/20 | 0.43 |
| ▸ | USP2 | O75604 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | PDE4B | Q07343 | 4/20 | 0.39 |
| ▸ | JAK2 | O60674 | 1/20 | 0.39 |
| ▸ | JAK1 | P23458 | 1/20 | 0.39 |
| ▸ | RECQL | P46063 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16110102 | 0.97 | DDB1 (0.58) | DDB1CRBNEPHX1HPGDNR1H2 | |
| SCHEMBL16110085 | 0.92 | DDB1 (0.59) | DDB1CRBNEPHX1HPGDNR1H2 | |
| SCHEMBL2953243 | 0.88 | EPHX1 (0.58) | EPHX1HPGDMEN1MAPTKMT2A | |
| SCHEMBL34473785 | 0.86 | USP30 (0.53) | DDB1CRBNEPHX1HPGDMEN1 | |
| SCHEMBL19717593 | 0.84 | HPGD (0.56) | EPHX1HPGDMEN1MAPTKMT2A | |
| SCHEMBL20063733 | 0.82 | DDB1 (0.51) | DDB1CRBNEPHX1HPGDNR1H2 | |
| SCHEMBL20521571 | 0.81 | USP30 (0.54) | DDB1CRBNEPHX1HPGDUSP30 | |
| SCHEMBL3563885 | 0.80 | DDB1 (0.52) | DDB1CRBNEPHX1HPGDNR1H2 | |
| SCHEMBL19633473 | 0.79 | HPGD (0.54) | EPHX1HPGDUSP2SMN1; SMN2RECQL | |
| SCHEMBL26666918 | 0.79 | DDB1 (0.52) | DDB1CRBNEPHX1HPGDNR1H2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022266258-A1 | COMPOUNDS AND METHODS FOR THE TARGETED DEGRADATION OF IRAK-4 | ARVINAS OPERATIONS, INC. (US) | 2022-12-22 | — | — | WO | disclosed |