SCHEMBL24780434 — predicted protein targets

Predicted protein targets (top 15)

	gene	UniProt	supporting neighbours	confidence
▸	EGFR	P00533	3/20	0.44

▸	RET	P07949	5/20	0.40

▸	ACVR1	Q04771	2/20	0.40

▸	PTK2	Q05397	1/20	0.40

▸	CHEK1	O14757	1/20	0.38

▸	CCNA2	P20248	1/20	0.38

▸	CDK2	P24941	1/20	0.38

▸	CCNA1	P78396	1/20	0.38

▸	KIT	P10721	1/20	0.36

▸	FLT3	P36888	1/20	0.36

▸	IRAK4	Q9NWZ3	1/20	0.36

▸	USP28	Q96RU2	1/20	0.36

▸	USP25	Q9UHP3	1/20	0.36

▸	MAP4K3	Q8IVH8	1/20	0.36

▸	SCD	O00767	1/20	0.35

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compound	similarity	top predicted	shared targets
SCHEMBL22950983	0.93	EGFR (0.45)	EGFRRETACVR1PTK2SCD
SCHEMBL22950934	0.92	EGFR (0.45)	EGFRACVR1PTK2
SCHEMBL22950893	0.91	EGFR (0.51)	EGFRACVR1PTK2
SCHEMBL29757784	0.91	EGFR (0.51)	EGFRACVR1PTK2
SCHEMBL27161995	0.91	EGFR (0.38)	EGFRRETACVR1PTK2CHEK1
SCHEMBL23442017	0.89	MAPK8 (0.44)	EGFRRETACVR1IRAK4
SCHEMBL31285030	0.89	MAPK8 (0.44)	EGFRRETACVR1IRAK4
SCHEMBL23759769	0.89	EGFR (0.48)	EGFRRETACVR1PTK2
SCHEMBL22950966	0.88	EGFR (0.43)	EGFRRETACVR1PTK2CHEK1
SCHEMBL29877257	0.88	RET (0.39)	EGFRRETCHEK1CCNA2CDK2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

Patent	Title	Assignee	Published	Priority	Filing	Country	Status
WO-2022262857-A1	ARYLPHOSPHINE OXIDE COMPOUNDS	微境生物医药科技(上海)有限公司	2022-12-22	—	—	WO	disclosed