Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TDP1 | Q9NUW8 | 7/20 | 0.62 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.62 |
| ▸ | NR2E3 | Q9Y5X4 | 3/20 | 0.62 |
| ▸ | HPGD | P15428 | 3/20 | 0.62 |
| ▸ | PPARG | P37231 | 2/20 | 0.62 |
| ▸ | NCOR2 | Q9Y618 | 2/20 | 0.62 |
| ▸ | MAPK10 | P53779 | 2/20 | 0.62 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.62 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.62 |
| ▸ | ABL1 | P00519 | 7/20 | 0.56 |
| ▸ | RIN1 | Q13671 | 7/20 | 0.56 |
| ▸ | IDE | P14735 | 1/20 | 0.56 |
| ▸ | NSD2 | O96028 | 3/20 | 0.54 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.54 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.54 |
| ▸ | LMNA | P02545 | 2/20 | 0.53 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.48 |
| ▸ | TSHR | P16473 | 1/20 | 0.48 |
| ▸ | HTT | P42858 | 1/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22652931 | 0.89 | TDP1 (0.61) | TDP1ALDH1A1NR2E3HPGDPPARG | |
| SCHEMBL24780647 | 0.87 | TDP1 (0.59) | TDP1ALDH1A1NR2E3HPGDPPARG | |
| SCHEMBL16471801 | 0.86 | TDP1 (0.66) | TDP1ALDH1A1NR2E3HPGDPPARG | |
| SCHEMBL20635796 | 0.86 | TDP1 (0.66) | TDP1ALDH1A1NR2E3HPGDPPARG | |
| SCHEMBL21957563 | 0.86 | TDP1 (0.66) | TDP1ALDH1A1NR2E3HPGDPPARG | |
| SCHEMBL18501106 | 0.86 | TDP1 (0.66) | TDP1ALDH1A1NR2E3HPGDPPARG | |
| SCHEMBL24604564 | 0.85 | TDP1 (0.57) | TDP1ALDH1A1NR2E3HPGDPPARG | |
| SCHEMBL13079423 | 0.85 | TDP1 (0.65) | TDP1ALDH1A1NR2E3HPGDPPARG | |
| SCHEMBL3761526 | 0.85 | TDP1 (0.65) | TDP1ALDH1A1NR2E3HPGDPPARG | |
| SCHEMBL13049466 | 0.85 | TDP1 (0.65) | TDP1ALDH1A1NR2E3HPGDPPARG |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20220402869-A1 | TRANSCRIPTIONAL ENHANCED ASSOCIATE DOMAIN (TEAD) TRANSCRIPTION FACTOR INHIBITORS AND USES THEREOF | DANA-FARBER CANCER INSTITUTE, INC. (US) | 2022-12-22 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20220402869-A1 | TRANSCRIPTIONAL ENHANCED ASSOCIATE DOMAIN (TEAD) TRANSCRIPTION FACTOR INHIBITORS AND USES THEREOF | TEAD1, TEAD4, TEAD2 | TDP1 743/4885ALDH1A1 2662/4885NR2E3 639/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.