Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PLK1 | P53350 | 18/20 | 0.78 |
| ▸ | BRD4 | O60885 | 9/20 | 0.78 |
| ▸ | PLK3 | Q9H4B4 | 8/20 | 0.68 |
| ▸ | PLK2 | Q9NYY3 | 6/20 | 0.68 |
| ▸ | PTK2 | Q05397 | 5/20 | 0.68 |
| ▸ | BRDT | Q58F21 | 4/20 | 0.68 |
| ▸ | PDXK | O00764 | 2/20 | 0.68 |
| ▸ | NEK3 | P51956 | 2/20 | 0.68 |
| ▸ | CAMKK2 | Q96RR4 | 2/20 | 0.68 |
| ▸ | WEE1 | P30291 | 1/20 | 0.68 |
| ▸ | PRKD3 | O94806 | 3/20 | 0.63 |
| ▸ | CLK2 | P49760 | 3/20 | 0.63 |
| ▸ | CAMK2G | Q13555 | 3/20 | 0.63 |
| ▸ | CAMK2D | Q13557 | 3/20 | 0.63 |
| ▸ | PRKD2 | Q9BZL6 | 3/20 | 0.63 |
| ▸ | CSNK1G1 | Q9HCP0 | 3/20 | 0.63 |
| ▸ | CSNK1G3 | Q9Y6M4 | 3/20 | 0.63 |
| ▸ | MAP4K4 | O95819 | 2/20 | 0.63 |
| ▸ | PRKCG | P05129 | 2/20 | 0.63 |
| ▸ | RPS6KA3 | P51812 | 2/20 | 0.63 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12324588 | 0.92 | PLK1 (0.75) | PLK1BRD4PLK3PLK2PTK2 | |
| SCHEMBL12323787 | 0.92 | PLK1 (0.78) | PLK1BRD4PLK3PLK2PTK2 | |
| SCHEMBL12323788 | 0.92 | PLK1 (0.75) | PLK1BRD4PLK3PLK2PTK2 | |
| SCHEMBL28344864 | 0.92 | PLK1 (0.78) | PLK1BRD4PLK3PLK2PTK2 | |
| SCHEMBL3644074 | 0.91 | PLK1 (0.74) | PLK1BRD4PLK3PLK2PTK2 | |
| SCHEMBL31467393 | 0.91 | PLK1 (0.74) | PLK1BRD4PLK3PLK2PTK2 | |
| SCHEMBL18636897 | 0.89 | PLK1 (0.89) | PLK1BRD4PLK3PLK2PTK2 | |
| SCHEMBL23289012 | 0.89 | PLK1 (0.89) | PLK1BRD4PLK3PLK2PTK2 | |
| SCHEMBL24782954 | 0.87 | PLK1 (0.78) | PLK1BRD4PLK3PLK2PTK2 | |
| SCHEMBL12956560 | 0.85 | PLK1 (0.69) | PLK1BRD4PLK3PLK2PTK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022261235-A1 | NON-PEPTIDE TARGETED THERAPEUTICS AND USES THEREOF | Crinetics Pharmaceuticals, Inc. (US) | 2022-12-15 | — | — | WO | disclosed |