Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK2 | O60674 | 11/20 | 0.41 |
| ▸ | JAK3 | P52333 | 10/20 | 0.41 |
| ▸ | JAK1 | P23458 | 7/20 | 0.37 |
| ▸ | EPHX2 | P34913 | 5/20 | 0.33 |
| ▸ | DGAT1 | O75907 | 1/20 | 0.32 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2480229 | 0.95 | JAK2 (0.47) | JAK2JAK3JAK1DGAT1GRIN2B | |
| SCHEMBL2476079 | 0.95 | JAK2 (0.45) | JAK2JAK3JAK1DGAT1GRIN2B | |
| SCHEMBL2378005 | 0.91 | JAK2 (0.50) | JAK2JAK3JAK1EPHX2DGAT1 | |
| SCHEMBL2375958 | 0.91 | JAK2 (0.50) | JAK2JAK3JAK1EPHX2DGAT1 | |
| SCHEMBL2375949 | 0.91 | JAK2 (0.50) | JAK2JAK3JAK1EPHX2DGAT1 | |
| SCHEMBL2378300 | 0.91 | JAK2 (0.42) | JAK2JAK3JAK1 | |
| SCHEMBL2378601 | 0.91 | JAK2 (0.42) | JAK2JAK3JAK1 | |
| SCHEMBL2378282 | 0.91 | JAK2 (0.42) | JAK2JAK3JAK1 | |
| SCHEMBL2378776 | 0.88 | JAK2 (0.48) | JAK2JAK3JAK1EPHX2 | |
| SCHEMBL2377720 | 0.88 | JAK2 (0.54) | JAK2JAK3JAK1EPHX2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2373653-A1 | PYRROLOPYRAZINYL UREA KINASE INHIBITORS | F. Hoffmann-La Roche AG (CH) | 2011-10-12 | — | — | EP | disclosed |
| WO-2010063634-A1 | PYRROLOPYRAZINYL UREA KINASE INHIBITORS | F. HOFFMANN-LA ROCHE AG (CH) | 2010-06-10 | — | — | WO | disclosed |