Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK2 | O60674 | 4/20 | 0.49 |
| ▸ | TYK2 | P29597 | 17/20 | 0.42 |
| ▸ | JAK1 | P23458 | 8/20 | 0.41 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.38 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.37 |
| ▸ | STAT3 | P40763 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24783620 | 0.89 | JAK2 (0.65) | JAK2TYK2JAK1CYP2C19 | |
| SCHEMBL24782595 | 0.88 | JAK2 (0.49) | JAK2TYK2JAK1KCNH2STAT3 | |
| SCHEMBL24784226 | 0.87 | JAK2 (0.46) | JAK2TYK2JAK1KCNH2STAT3 | |
| SCHEMBL24784196 | 0.84 | JAK2 (0.51) | JAK2TYK2JAK1CYP2C19KCNH2 | |
| SCHEMBL24782692 | 0.82 | JAK2 (0.48) | JAK2TYK2JAK1KCNH2STAT3 | |
| SCHEMBL24782586 | 0.80 | TYK2 (0.46) | JAK2TYK2JAK1CYP2C19KCNH2 | |
| SCHEMBL24782592 | 0.80 | JAK2 (0.45) | JAK2TYK2JAK1CYP2C19KCNH2 | |
| SCHEMBL24782591 | 0.80 | JAK2 (0.44) | JAK2TYK2JAK1CYP2C19KCNH2 | |
| SCHEMBL24782774 | 0.79 | JAK2 (0.69) | JAK2TYK2JAK1CYP2C19 | |
| SCHEMBL24782590 | 0.78 | JAK2 (0.50) | JAK2TYK2JAK1CYP2C19KCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022261524-A1 | HETEROARYL COMPOUNDS AS INHIBITORS OF TYK2, COMPOSITION AND APPLICATION THEREOF | ACCRO BIOSCIENCE (HK) LIMITED (CN) | 2022-12-15 | — | — | WO | disclosed |