Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TYK2 | P29597 | 20/20 | 0.33 |
| ▸ | JAK1 | P23458 | 2/20 | 0.33 |
| ▸ | JAK2 | O60674 | 1/20 | 0.31 |
| ▸ | STAT3 | P40763 | 1/20 | 0.30 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24782692 | 0.80 | JAK2 (0.48) | TYK2JAK1JAK2STAT3KCNH2 | |
| SCHEMBL26983763 | 0.78 | TLR8 (0.35) | — | |
| SCHEMBL30051006 | 0.78 | TLR8 (0.35) | — | |
| SCHEMBL24783424 | 0.77 | TYK2 (0.43) | TYK2JAK1JAK2STAT3 | |
| SCHEMBL30780309 | 0.76 | TYK2 (0.40) | TYK2JAK2 | |
| SCHEMBL26983755 | 0.76 | TYK2 (0.40) | TYK2JAK2 | |
| SCHEMBL24782595 | 0.72 | JAK2 (0.49) | TYK2JAK1JAK2STAT3KCNH2 | |
| SCHEMBL30780306 | 0.72 | TYK2 (0.56) | TYK2JAK1JAK2STAT3 | |
| SCHEMBL26983730 | 0.72 | TYK2 (0.56) | TYK2JAK1JAK2STAT3 | |
| SCHEMBL26991434 | 0.72 | TYK2 (0.43) | TYK2JAK1JAK2STAT3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022261524-A1 | HETEROARYL COMPOUNDS AS INHIBITORS OF TYK2, COMPOSITION AND APPLICATION THEREOF | ACCRO BIOSCIENCE (HK) LIMITED (CN) | 2022-12-15 | — | — | WO | disclosed |