Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK2 | O60674 | 3/20 | 0.66 |
| ▸ | TYK2 | P29597 | 18/20 | 0.57 |
| ▸ | JAK1 | P23458 | 3/20 | 0.56 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24782774 | 0.92 | JAK2 (0.69) | JAK2TYK2JAK1CYP2C19 | |
| SCHEMBL24783620 | 0.90 | JAK2 (0.65) | JAK2TYK2JAK1CYP2C19 | |
| SCHEMBL24782779 | 0.88 | TYK2 (0.56) | JAK2TYK2JAK1 | |
| SCHEMBL24782602 | 0.86 | JAK2 (0.68) | JAK2TYK2JAK1CYP2C19 | |
| SCHEMBL24784226 | 0.86 | JAK2 (0.46) | JAK2TYK2JAK1 | |
| SCHEMBL24782611 | 0.86 | JAK2 (0.67) | JAK2TYK2JAK1CYP2C19 | |
| SCHEMBL24784211 | 0.84 | TYK2 (0.67) | JAK2TYK2JAK1CYP2C19 | |
| SCHEMBL24782583 | 0.84 | JAK2 (0.45) | JAK2TYK2JAK1CYP2C19 | |
| SCHEMBL24782775 | 0.84 | JAK2 (0.65) | JAK2TYK2JAK1CYP2C19 | |
| SCHEMBL24784213 | 0.84 | JAK2 (0.64) | JAK2TYK2JAK1CYP2C19 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022261524-A1 | HETEROARYL COMPOUNDS AS INHIBITORS OF TYK2, COMPOSITION AND APPLICATION THEREOF | ACCRO BIOSCIENCE (HK) LIMITED (CN) | 2022-12-15 | — | — | WO | disclosed |