Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CDK2 | P24941 | 9/20 | 0.60 |
| ▸ | CDK7 | P50613 | 8/20 | 0.60 |
| ▸ | CCNE1 | P24864 | 5/20 | 0.60 |
| ▸ | CCNH | P51946 | 5/20 | 0.60 |
| ▸ | MNAT1 | P51948 | 5/20 | 0.60 |
| ▸ | CDK1 | P06493 | 4/20 | 0.60 |
| ▸ | CDK9 | P50750 | 3/20 | 0.60 |
| ▸ | CDK5 | Q00535 | 3/20 | 0.60 |
| ▸ | CDK4 | P11802 | 2/20 | 0.60 |
| ▸ | CDK6 | Q00534 | 2/20 | 0.60 |
| ▸ | CDK8 | P49336 | 1/20 | 0.60 |
| ▸ | CSNK2A2 | P19784 | 4/20 | 0.48 |
| ▸ | CHEK1 | O14757 | 3/20 | 0.40 |
| ▸ | CCNA2 | P20248 | 3/20 | 0.40 |
| ▸ | CCNA1 | P78396 | 2/20 | 0.40 |
| ▸ | GSK3B | P49841 | 2/20 | 0.39 |
| ▸ | GPR39 | O43194 | 1/20 | 0.38 |
| ▸ | DYRK3 | O43781 | 1/20 | 0.36 |
| ▸ | CCNT1 | O60563 | 1/20 | 0.36 |
| ▸ | CLK1 | P49759 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24793471 | 0.91 | CDK7 (0.68) | CDK2CDK7CCNE1CCNHMNAT1 | |
| SCHEMBL24792712 | 0.89 | CDK2 (0.63) | CDK2CDK7CCNE1CCNHMNAT1 | |
| SCHEMBL24792773 | 0.89 | CDK2 (0.63) | CDK2CDK7CCNE1CCNHMNAT1 | |
| SCHEMBL24792778 | 0.88 | CDK2 (0.57) | CDK2CDK7CCNE1CCNHMNAT1 | |
| SCHEMBL24792717 | 0.88 | CDK2 (0.63) | CDK2CDK7CCNE1CCNHMNAT1 | |
| SCHEMBL24791458 | 0.87 | CDK7 (0.81) | CDK2CDK7CCNE1CCNHMNAT1 | |
| SCHEMBL24791518 | 0.87 | CSNK2A2 (0.54) | CDK2CDK7CCNE1CCNHMNAT1 | |
| SCHEMBL24792979 | 0.85 | CSNK2A2 (0.53) | CDK2CDK7CCNE1CCNHMNAT1 | |
| SCHEMBL30083569 | 0.81 | CDK2 (0.57) | CDK2CDK7CCNE1CCNHMNAT1 | |
| SCHEMBL24791462 | 0.81 | CDK7 (0.63) | CDK2CDK7CCNE1CCNHMNAT1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4355426-A1 | SUBSTITUTED PYRAZOLO[1,5-A]PYRIMIDINE-7-AMINE COMPOUNDS AS CDK INHIBITORS AND THEIR THERAPEUTIC USE | Carrick Therapeutics Limited (IE) | 2024-04-24 | — | — | EP | disclosed |
| WO-2022263604-A1 | SUBSTITUTED PYRAZOLO[1,5-A]PYRIMIDINE-7-AMINE COMPOUNDS AS CDK INHIBITORS AND THEIR THERAPEUTIC USE | Carrick Therapeutics Limited (IE) | 2022-12-22 | — | — | WO | disclosed |
| WO-2022263604-A1 | SUBSTITUTED PYRAZOLO[1,5-A]PYRIMIDINE-7-AMINE COMPOUNDS AS CDK INHIBITORS AND THEIR THERAPEUTIC USE | Carrick Therapeutics Limited (IE) | 2022-12-22 | — | — | WO | disclosed |