Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CDK7 | P50613 | 9/20 | 0.58 |
| ▸ | CDK2 | P24941 | 8/20 | 0.58 |
| ▸ | CCNE1 | P24864 | 6/20 | 0.58 |
| ▸ | CCNH | P51946 | 6/20 | 0.58 |
| ▸ | MNAT1 | P51948 | 6/20 | 0.58 |
| ▸ | CDK1 | P06493 | 5/20 | 0.58 |
| ▸ | CDK9 | P50750 | 3/20 | 0.58 |
| ▸ | CDK4 | P11802 | 2/20 | 0.58 |
| ▸ | CDK6 | Q00534 | 2/20 | 0.58 |
| ▸ | CDK5 | Q00535 | 2/20 | 0.58 |
| ▸ | CDK8 | P49336 | 1/20 | 0.58 |
| ▸ | CHEK1 | O14757 | 4/20 | 0.40 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.40 |
| ▸ | CCNA1 | P78396 | 1/20 | 0.40 |
| ▸ | GSK3B | P49841 | 2/20 | 0.38 |
| ▸ | IRAK4 | Q9NWZ3 | 2/20 | 0.35 |
| ▸ | GPR39 | O43194 | 1/20 | 0.34 |
| ▸ | P2RX3 | P56373 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30083625 | 0.90 | CDK7 (0.64) | CDK7CDK2CCNE1CCNHMNAT1 | |
| SCHEMBL24791465 | 0.90 | CDK7 (0.64) | CDK7CDK2CCNE1CCNHMNAT1 | |
| SCHEMBL24792712 | 0.89 | CDK2 (0.63) | CDK7CDK2CCNE1CCNHMNAT1 | |
| SCHEMBL24792823 | 0.88 | CDK7 (0.55) | CDK7CDK2CCNE1CCNHMNAT1 | |
| SCHEMBL24793474 | 0.87 | CDK7 (0.70) | CDK7CDK2CCNE1CCNHMNAT1 | |
| SCHEMBL24792806 | 0.87 | CDK7 (0.58) | CDK7CDK2CCNE1CCNHMNAT1 | |
| SCHEMBL24791462 | 0.86 | CDK7 (0.63) | CDK7CDK2CCNE1CCNHMNAT1 | |
| SCHEMBL20848289 | 0.85 | CDK7 (0.77) | CDK7CDK2CCNE1CCNHMNAT1 | |
| SCHEMBL24792388 | 0.84 | CDK7 (0.59) | CDK7CDK2CCNE1CCNHMNAT1 | |
| SCHEMBL24792802 | 0.84 | CDK7 (0.58) | CDK7CDK2CCNE1CCNHMNAT1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4355426-A1 | SUBSTITUTED PYRAZOLO[1,5-A]PYRIMIDINE-7-AMINE COMPOUNDS AS CDK INHIBITORS AND THEIR THERAPEUTIC USE | Carrick Therapeutics Limited (IE) | 2024-04-24 | — | — | EP | disclosed |
| WO-2022263604-A1 | SUBSTITUTED PYRAZOLO[1,5-A]PYRIMIDINE-7-AMINE COMPOUNDS AS CDK INHIBITORS AND THEIR THERAPEUTIC USE | Carrick Therapeutics Limited (IE) | 2022-12-22 | — | — | WO | disclosed |
| WO-2022263604-A1 | SUBSTITUTED PYRAZOLO[1,5-A]PYRIMIDINE-7-AMINE COMPOUNDS AS CDK INHIBITORS AND THEIR THERAPEUTIC USE | Carrick Therapeutics Limited (IE) | 2022-12-22 | — | — | WO | disclosed |