Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 1/20 | 0.53 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.53 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.53 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.53 |
| ▸ | HTR2A | P28223 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
| ▸ | TAOK1 | Q7L7X3 | 1/20 | 0.37 |
| ▸ | TAOK3 | Q9H2K8 | 1/20 | 0.37 |
| ▸ | PIN1 | Q13526 | 1/20 | 0.36 |
| ▸ | DRD2 | P14416 | 1/20 | 0.36 |
| ▸ | DRD1 | P21728 | 1/20 | 0.36 |
| ▸ | ATM | Q13315 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.35 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.35 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.35 |
| ▸ | TSHR | P16473 | 1/20 | 0.35 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.35 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29921534 | 1.00 | MEN1 (0.53) | MEN1CYP3A4CYP2D6KMT2AHTR2A | |
| SCHEMBL1338359 | 0.84 | MEN1 (0.54) | MEN1CYP3A4CYP2D6KMT2AHTR2A | |
| SCHEMBL29595365 | 0.84 | MEN1 (0.54) | MEN1CYP3A4CYP2D6KMT2AHTR2A | |
| SCHEMBL6601826 | 0.83 | HTR2C (0.54) | CYP3A4HTR2AALDH1A1GAAPIN1 | |
| Hydrochloric Acid SCHEMBL27476431 | 0.83 | MEN1 (0.53) | MEN1CYP3A4CYP2D6KMT2AHTR2A | |
| SCHEMBL27538575 | 0.83 | CYP2D6 (0.49) | MEN1CYP3A4CYP2D6KMT2AHTR2A | |
| Acetic Acid SCHEMBL27449656 | 0.80 | MEN1 (0.50) | MEN1CYP3A4CYP2D6KMT2AHTR2A | |
| SCHEMBL27909506 | 0.80 | HDAC4 (0.50) | MEN1CYP3A4CYP2D6KMT2AHTR2A | |
| SCHEMBL3702121 | 0.79 | CYP2D6 (0.45) | MEN1CYP3A4CYP2D6KMT2AHTR2A | |
| Hydrochloric Acid SCHEMBL27924558 | 0.78 | CYP2D6 (0.44) | MEN1CYP3A4CYP2D6KMT2AHTR2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 38 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4322949-A1 | ISOQUINOLINE DERIVATIVES FOR USE AS ANTIVIRAL AND ANTITUMOUR AGENTS | RDP Pharma AG (CH) | 2024-02-21 | — | — | EP | claimed |
| EP-4132918-A1 | NEW ANTI-MALARIAL AGENTS | University Of Kentucky Research Foundation (US) | 2023-02-15 | — | — | EP | claimed |
| CN-103930404-B | Substituted 2-alkyl-1-oxo-N-phenyl-3-heteroaryl-1, 2,3, 4-tetrahydroisoquinoline-4-amides for use in a method of treatment against malaria | 圣朱德儿童研究医院 | 2016-08-24 | — | — | CN | claimed |
| EP-2748147-A1 | SUBSTITUTED 2-ALKYL-1-OXO-N-PHENYL-3-HETEROARYL-1,2,3,4-TETRAHYDROISOQUINOLINE-4-CARBOXAMIDES FOR ANTIMALARIAL THERAPIES | St. Jude Children's Research Hospital (US) | 2014-07-02 | — | — | EP | claimed |
| WO-2013027196-A9 | SUBSTITUTED 2-ALKYL-1-OXO-N-PHENYL-3-HETEROARYL-1,2,3,4- TETRAHYDROISOQUINOLINE-4-CARBOXAMIDES FOR ANTIMALARIAL THERAPIES | ST. JUDE CHILDREN'S RESEARCH HOSPITAL (US) | 2013-04-18 | — | — | WO | claimed |
| WO-2013027196-A1 | SUBSTITUTED 2-ALKYL-1-OXO-N-PHENYL-3-HETEROARYL-1,2,3,4- TETRAHYDROISOQUINOLINE-4-CARBOXAMIDES FOR ANTIMALARIAL THERAPIES | ST. JUDE CHILDREN'S RESEARCH HOSPITAL (US) | 2013-02-28 | — | — | WO | claimed |
| EP-4322949-A1 | ISOQUINOLINE DERIVATIVES FOR USE AS ANTIVIRAL AND ANTITUMOUR AGENTS | RDP Pharma AG (CH) | 2024-02-21 | — | — | EP | disclosed |
| WO-2023226965-A1 | ROCK INHIBITORS AND USES THEREOF | DIZAL (JIANGSU) PHARMACEUTICAL CO., LTD. (CN) | 2023-11-30 | — | — | WO | disclosed |
| WO-2019242599-A1 | TETRAHYDRO ISOQUINOLINE DERIVATIVE, PREPARATION METHOD THEREFOR AND USE THEREOF | 浙江海正药业股份有限公司 | 2019-12-26 | — | — | WO | disclosed |
| CN-108463458-A | MODULATORS OF ROR-GAMMA | 生命医药公司 | 2018-08-28 | — | — | CN | disclosed |
| US-9975853-B2 | Tetrahydroisoquinolinone derivatives and their use in the inhibition of the HSP70 protein | JULIUS-MAXIMILIANS-UNIVERSITAET WUERZBURG (DE) | 2018-05-22 | — | — | US | disclosed |
| EP-3152193-B1 | TETRAHYDROISOQUINOLINONE DERIVATIVES AND THEIR USE IN THE INHIBITION OF THE HSP70 PROTEIN | HOLZGRABE ULRIKE (DE) | 2018-03-28 | — | — | EP | disclosed |
| EP-3204359-A1 | TETRAHYDROISOQUINOLINE DERIVATIVES | UCB Biopharma SPRL (BE) | 2017-08-16 | — | — | EP | disclosed |
| WO-2008074832-A2 | ISOQUINOLINECARBOXAMIDES AS INHIBITORS OF STEAROYL-COA DESATURASE ( SCD) | SMITHKLINE BEECHAM CORPORATION (US) | 2008-06-26 | — | — | WO | disclosed |
| WO-2008074824-A2 | ISOQUINOLINECARBOXAMIDES AS INHIBITORS OF STEAROYL-COA DESATURASE (SCD) | SMITHKLINE BEECHAM CORPORATION (US) | 2008-06-26 | — | — | WO | disclosed |
| EP-1417190-A1 | SUBSTITUTED PIPERAZINES AS MODULATORS OF THE MELANOCORTIN RECEPTOR | Amgen Inc. (US) | 2004-05-12 | — | — | EP | disclosed |
| WO-2003009850-A1 | SUBSTITUTED PIPERAZINES AS MODULATORS OF THE MELANOCORTIN RECEPTOR | AMGEN INC. (US) | 2003-02-06 | — | — | WO | disclosed |
| EP-0986552-A1 | 5-NAPHTHALEN-1-YL-1,3-DIOXANE DERIVATIVES, PREPARATION AND THERAPEUTIC APPLICATION | SANOFI-SYNTHELABO (FR) | 2000-03-22 | — | — | EP | disclosed |
| WO-1998055474-A1 | 5-NAPHTHALEN-1-YL-1,3-DIOXANE DERIVATIVES, PREPARATION AND THERAPEUTIC APPLICATION | SANOFI-SYNTHELABO (FR) | 1998-12-10 | — | — | WO | disclosed |
| EP-0563132-A1 | TETRAPEPTIDE DERIVATIVES AND ANALOGUES. | BLACK JAMES FOUNDATION (GB) | 1993-10-06 | — | — | EP | disclosed |