Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2C | P28335 | 9/20 | 0.52 |
| ▸ | HTR2A | P28223 | 8/20 | 0.52 |
| ▸ | HTR1A | P08908 | 4/20 | 0.52 |
| ▸ | DRD2 | P14416 | 4/20 | 0.52 |
| ▸ | HTR7 | P34969 | 4/20 | 0.52 |
| ▸ | DRD3 | P35462 | 4/20 | 0.52 |
| ▸ | HTR6 | P50406 | 4/20 | 0.52 |
| ▸ | HTR2B | P41595 | 4/20 | 0.52 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.52 |
| ▸ | KDR | P35968 | 3/20 | 0.48 |
| ▸ | CHUK | O15111 | 1/20 | 0.43 |
| ▸ | EGFR | P00533 | 1/20 | 0.43 |
| ▸ | BCL6 | P41182 | 2/20 | 0.41 |
| ▸ | MAPT | P10636 | 2/20 | 0.40 |
| ▸ | VCP | P55072 | 1/20 | 0.38 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2854741 | 0.77 | EGFR (0.46) | HTR2CHTR2AHTR1ADRD2HTR7 | |
| Hydrochloric Acid SCHEMBL6385574 | 0.76 | MAPT (0.43) | HTR2CHTR2AHTR1ADRD2HTR7 | |
| SCHEMBL12426177 | 0.76 | HTR2C (0.55) | HTR2CHTR2AHTR1ADRD2HTR7 | |
| SCHEMBL14086114 | 0.73 | TRPV1 (0.53) | HTR2CHTR2ATRPV1 | |
| SCHEMBL20298995 | 0.71 | TOP2A (0.45) | HTR2CHTR2AHTR2BTRPV1 | |
| SCHEMBL2450338 | 0.71 | SYK (0.41) | HTR2CHTR2AHTR1ADRD2HTR7 | |
| SCHEMBL3635486 | 0.69 | KDR (0.54) | KDRCHUKEGFRBCL6MAPT | |
| SCHEMBL4868221 | 0.69 | HTR2A (0.48) | HTR2CHTR2AHTR1ADRD2HTR7 | |
| SCHEMBL16167172 | 0.69 | CD44 (0.38) | HTR2CHTR2AHTR2BMAPT | |
| SCHEMBL15662918 | 0.69 | MAPK14 (0.48) | HTR2CHTR2AHTR7HTR2BMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2367826-A1 | MODULATORS OF AMYLOID BETA. | AstraZeneca AB (SE) | 2011-09-28 | — | — | EP | disclosed |
| WO-2010053438-A1 | MODULATORS OF AMYLOID BETA. | ASTRAZENECA AB (SE) | 2010-05-14 | — | — | WO | disclosed |