⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24809433 | 0.84 | RXFP1 (0.30) | — | |
| SCHEMBL24811114 | 0.83 | PDCD1LG2 (0.30) | — | |
| SCHEMBL24809346 | 0.83 | ASAH1 (0.38) | — | |
| SCHEMBL24809410 | 0.81 | HPGD (0.38) | — | |
| SCHEMBL24809412 | 0.79 | BRD4 (0.36) | — | |
| SCHEMBL24810815 | 0.77 | PDE10A (0.38) | — | |
| SCHEMBL24809680 | 0.76 | — | — | |
| SCHEMBL24809756 | 0.74 | ASAH1 (0.36) | — | |
| SCHEMBL24809406 | 0.73 | NAMPT (0.36) | — | |
| SCHEMBL24809400 | 0.73 | ASAH1 (0.48) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20220411388-A1 | SUBSTITUTED IMIDAZOLE CARBOXAMIDES AND THEIR USE IN THE TREATMENT OF MEDICAL DISORDERS | BIAL R&D INVEST S A (PT) | 2022-12-29 | — | — | US | disclosed |
| EP-4031531-A1 | SUBSTITUTED IMIDAZOLE CARBOXAMIDES AND THEIR USE IN THE TREATMENT OF MEDICAL DISORDERS | Bial-R&D Investments, S.A. (PT) | 2022-07-27 | — | — | EP | disclosed |
| CN-114787135-A | Substituted imidazole carboxamides and their use in the treatment of medical disorders | 比亚尔R&D投资股份公司 | 2022-07-22 | — | — | CN | disclosed |