Predicted protein targets (top 2)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH3A1 | P30838 | 1/20 | 0.49 |
| ▸ | BCL2 | P10415 | 11/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30314086 | 0.87 | BCL2 (0.64) | BCL2 | |
| SCHEMBL1958805 | 0.82 | BCL2 (0.62) | BCL2 | |
| SCHEMBL2775444 | 0.80 | BCL2 (0.60) | BCL2 | |
| SCHEMBL28102788 | 0.80 | MAPK1 (0.44) | ALDH3A1BCL2 | |
| SCHEMBL2776802 | 0.78 | BCL2 (0.61) | BCL2 | |
| SCHEMBL29796315 | 0.78 | BCL2 (0.64) | BCL2 | |
| SCHEMBL3398579 | 0.77 | BCL2 (0.53) | BCL2 | |
| SCHEMBL1956566 | 0.77 | BCL2 (0.56) | BCL2 | |
| SCHEMBL1955838 | 0.76 | BCL2 (0.68) | BCL2 | |
| SCHEMBL1957963 | 0.76 | BCL2 (0.60) | BCL2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2376480-A2 | SULFONAMIDE DERIVATIVES AS BCL-2-SELECTIVE APOPTOSIS-INDUCING AGENTS FOR THE TREATMENT OF CANCER AND IMMUNE DISEASES | Abbott Laboratories (US) | 2011-10-19 | — | — | EP | claimed |
| WO-2010065865-A2 | BCL-2-SELECTIVE APOPTOSIS-INDUCING AGENTS FOR THE TREATMENT OF CANCER AND IMMUNE DISEASES | ABBOTT LABORATORIES (US) | 2010-06-10 | — | — | WO | claimed |
| EP-2376480-A2 | SULFONAMIDE DERIVATIVES AS BCL-2-SELECTIVE APOPTOSIS-INDUCING AGENTS FOR THE TREATMENT OF CANCER AND IMMUNE DISEASES | Abbott Laboratories (US) | 2011-10-19 | — | — | EP | disclosed |
| WO-2010065865-A2 | BCL-2-SELECTIVE APOPTOSIS-INDUCING AGENTS FOR THE TREATMENT OF CANCER AND IMMUNE DISEASES | ABBOTT LABORATORIES (US) | 2010-06-10 | — | — | WO | disclosed |