Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CRBN | Q96SW2 | 18/20 | 0.70 |
| ▸ | DDB1 | Q16531 | 17/20 | 0.70 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.38 |
| ▸ | SRD5A2 | P31213 | 1/20 | 0.36 |
| ▸ | IKZF3 | Q9UKT9 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23842108 | 0.94 | DDB1 (0.72) | CRBNDDB1KDM4EALDH1A1MAPT | |
| SCHEMBL23541139 | 0.90 | DDB1 (0.64) | CRBNDDB1KDM4EALDH1A1MAPT | |
| SCHEMBL23541310 | 0.87 | CRBN (0.63) | CRBNDDB1KDM4EALDH1A1MAPT | |
| SCHEMBL24821105 | 0.87 | CRBN (0.61) | CRBNDDB1KDM4EALDH1A1MAPT | |
| SCHEMBL22526812 | 0.86 | CRBN (0.69) | CRBNDDB1IKZF3 | |
| SCHEMBL30169143 | 0.86 | CRBN (0.69) | CRBNDDB1IKZF3 | |
| SCHEMBL26094177 | 0.85 | CRBN (0.72) | CRBNDDB1IKZF3 | |
| SCHEMBL24764216 | 0.84 | CRBN (0.76) | CRBNDDB1ALDH1A1IKZF3 | |
| SCHEMBL23842131 | 0.84 | CRBN (0.67) | CRBNDDB1 | |
| SCHEMBL23833043 | 0.84 | CRBN (0.69) | CRBNDDB1IKZF3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023019166-A1 | PROTEIN TYROSINE PHOSPHATASE TARGETING LIGANDS | CALICO LIFE SCIENCES LLC (US) | 2023-02-16 | — | — | WO | disclosed |
| WO-2023019166-A1 | PROTEIN TYROSINE PHOSPHATASE TARGETING LIGANDS | CALICO LIFE SCIENCES LLC (US) | 2023-02-16 | — | — | WO | disclosed |
| WO-2022271727-A1 | DEGRADER COMPOUNDS AND USES THEREOF | CALICO LIFE SCIENCES LLC (US) | 2022-12-29 | — | — | WO | disclosed |