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SCHEMBL24818860

SCHEMBL24818860

Cn1cnnc1-c1cc(F)ccc1-c1cccc(-c2nc3cc(CN4CCC5(CC4)CC5)cc(C(F)(F)F)c3[nH]2)c1

nearest known ligand 0.36

Predicted protein targets (top 11)

geneUniProtsupporting neighboursconfidence
▸ CBLB Q13191 14/20 0.36
▸ CYP3A4 P08684 1/20 0.33
▸ CNR1 P21554 2/20 0.32
▸ CNR2 P34972 2/20 0.32
▸ CBL P22681 1/20 0.31
▸ CDK1 P06493 1/20 0.31
▸ CDK2 P24941 1/20 0.31
▸ CDK9 P50750 1/20 0.31
▸ P2RX7 Q99572 1/20 0.31
▸ HCRTR1 O43613 1/20 0.30
▸ HCRTR2 O43614 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL30153086 1.00 CBLB (0.36) CBLBCYP3A4CNR1CNR2CBL
SCHEMBL30153085 1.00 CBLB (0.36) CBLBCYP3A4CNR1CNR2CBL
SCHEMBL30152842 0.89 CBLB (0.35) CBLBP2RX7HCRTR1HCRTR2
SCHEMBL24818746 0.89 CBLB (0.35) CBLBP2RX7HCRTR1HCRTR2
SCHEMBL30153026 0.88 CBLB (0.41) CBLBCBL
SCHEMBL24820284 0.88 CBLB (0.41) CBLBCBL
SCHEMBL24818660 0.87 CBLB (0.42) CBLBCNR2
SCHEMBL30152576 0.87 CBLB (0.42) CBLBCNR2
SCHEMBL24819959 0.86 CBLB (0.33) CBLBCBLP2RX7
SCHEMBL30152906 0.86 CBLB (0.33) CBLBCBLP2RX7

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2022272248-A1 CBL-B MODULATORS AND USES THEREOF NIMBUS CLIO, INC. (US) 2022-12-29 — — WO disclosed
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