Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CD | O00329 | 1/20 | 0.41 |
| ▸ | SOS1 | Q07889 | 1/20 | 0.38 |
| ▸ | PIK3R2 | O00459 | 4/20 | 0.37 |
| ▸ | PIK3CA | P42336 | 8/20 | 0.37 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.36 |
| ▸ | HTT | P42858 | 1/20 | 0.36 |
| ▸ | ATM | Q13315 | 1/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.36 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.36 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.36 |
| ▸ | PRKCQ | Q04759 | 1/20 | 0.35 |
| ▸ | PRKCD | Q05655 | 1/20 | 0.35 |
| ▸ | METAP1 | P53582 | 1/20 | 0.35 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.35 |
| ▸ | SMG1 | Q96Q15 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL246713 | 0.89 | PIK3R2 (0.47) | PIK3CDPIK3R2PIK3CAPIK3CBPIK3CG | |
| SCHEMBL247908 | 0.87 | PIK3CD (0.42) | PIK3CDPIK3R2PIK3CAATMPIK3CB | |
| SCHEMBL248827 | 0.86 | PIK3CD (0.41) | PIK3CDPIK3R2PIK3CAPIK3CBPIK3CG | |
| SCHEMBL249196 | 0.81 | PIK3CA (0.40) | PIK3CDSOS1PIK3R2PIK3CALRRK2 | |
| SCHEMBL2711238 | 0.81 | PIK3CD (0.48) | PIK3CDPIK3R2PIK3CAPIK3CBPIK3CG | |
| SCHEMBL13019249 | 0.80 | PIK3CA (0.43) | PIK3CDPIK3R2PIK3CAPIK3CBPIK3CG | |
| SCHEMBL248832 | 0.80 | ATR (0.42) | PIK3CDPIK3R2PIK3CASMG1 | |
| SCHEMBL247947 | 0.79 | PIK3CD (0.65) | PIK3CDPIK3CAPIK3CBPIK3CG | |
| SCHEMBL247875 | 0.77 | PIK3CA (0.49) | PIK3CDPIK3CAPIK3CBPIK3CGPDE4D | |
| SCHEMBL248526 | 0.76 | PIK3CD (0.59) | PIK3CDPIK3CALRRK2PIK3CBPIK3CG |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2588471-A1 | HETEROCYCLIC COMPOUNDS AND THEIR USE AS INHIBITORS OF PI3K ACTIVITY | Amgen Inc. (US) | 2013-05-08 | — | — | EP | disclosed |
| US-20130090323-A1 | HETEROCYCLIC COMPOUNDS AND THEIR USES | AMGEN INC. (US) | 2013-04-11 | — | — | US | disclosed |
| US-20130090323-A1 | HETEROCYCLIC COMPOUNDS AND THEIR USES | AMGEN INC. (US) | 2013-04-11 | — | — | US | disclosed |
| US-20130090323-A1 | HETEROCYCLIC COMPOUNDS AND THEIR USES | AMGEN INC. (US) | 2013-04-11 | — | — | US | disclosed |
| WO-2012003283-A1 | HETEROCYCLIC COMPOUNDS AND THEIR USE AS INHIBITORS OF PI3K ACTIVITY | AMGEN INC. (US) | 2012-01-05 | — | — | WO | disclosed |
| WO-2012003283-A1 | HETEROCYCLIC COMPOUNDS AND THEIR USE AS INHIBITORS OF PI3K ACTIVITY | AMGEN INC. (US) | 2012-01-05 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20130090323-A1 | HETEROCYCLIC COMPOUNDS AND THEIR USES | MCL1, MALT1, BCL9 | PIK3CD 24/4885SOS1 1106/4885PIK3R2 88/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.