Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK2 | O60674 | 19/20 | 0.47 |
| ▸ | PTK2 | Q05397 | 15/20 | 0.47 |
| ▸ | INSR | P06213 | 1/20 | 0.39 |
| ▸ | NPM1 | P06748 | 1/20 | 0.39 |
| ▸ | ALK | Q9UM73 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2482265 | 0.87 | JAK2 (0.45) | JAK2PTK2INSRNPM1ALK | |
| SCHEMBL519486 | 0.86 | JAK2 (0.65) | JAK2PTK2INSRNPM1ALK | |
| SCHEMBL16530330 | 0.76 | JAK2 (0.62) | JAK2PTK2INSRNPM1ALK | |
| SCHEMBL520127 | 0.73 | JAK2 (0.63) | JAK2PTK2INSRNPM1ALK | |
| SCHEMBL520717 | 0.71 | JAK2 (0.63) | JAK2PTK2INSRNPM1ALK | |
| SCHEMBL521205 | 0.70 | JAK2 (0.67) | JAK2PTK2INSRNPM1ALK | |
| SCHEMBL16530416 | 0.66 | JAK2 (0.65) | JAK2PTK2INSRNPM1ALK | |
| SCHEMBL520765 | 0.66 | JAK2 (0.75) | JAK2PTK2INSRNPM1ALK | |
| SCHEMBL522295 | 0.65 | ALK (0.56) | JAK2PTK2INSRALK | |
| SCHEMBL521111 | 0.64 | JAK2 (0.71) | JAK2PTK2INSRNPM1ALK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2376491-A1 | PYRROLOTRIAZINES AS ALK AND JAK2 INHIBITORS | Cephalon, Inc. (US) | 2011-10-19 | — | — | EP | disclosed |
| WO-2010071885-A1 | PYRROLOTRIAZINES AS ALK AND JAK2 INHIBITORS | CEPHALON, INC. (US) | 2010-06-24 | — | — | WO | disclosed |