SCHEMBL24819947

SCHEMBL24819947

Cn1cnnc1-c1cc(F)ccc1-c1cc(-c2nc3cc(CNCC4(O)CCCC4)ccc3o2)nc(C2CC2)c1

nearest known ligand 0.40

Predicted protein targets (top 5)

geneUniProtsupporting neighboursconfidence
▸ CBLB Q13191 1/20 0.40
▸ FASN P49327 1/20 0.30
▸ PDCD1 Q15116 1/20 0.30
▸ VSIR Q9H7M9 1/20 0.30
▸ CD274 Q9NZQ7 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL30152554 1.00 CBLB (0.40) CBLBFASNPDCD1VSIRCD274
SCHEMBL24819946 0.99 CBLB (0.42) CBLBFASNPDCD1VSIRCD274
SCHEMBL30153135 0.99 CBLB (0.42) CBLBFASNPDCD1VSIRCD274
SCHEMBL24820271 0.91 CBLB (0.40) CBLBFASN
SCHEMBL30152736 0.90 CBLB (0.37) CBLBPDCD1VSIRCD274
SCHEMBL24820525 0.90 CBLB (0.37) CBLBPDCD1VSIRCD274
SCHEMBL30152615 0.89 CBLB (0.42) CBLBVSIR
SCHEMBL24821978 0.89 CBLB (0.42) CBLBPDCD1VSIRCD274
SCHEMBL24819000 0.89 CBLB (0.42) CBLBVSIR
SCHEMBL30153059 0.89 CBLB (0.42) CBLBPDCD1VSIRCD274

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-117858865-A CBL-B modulators and uses thereof 林伯士克莱奥公司 2024-04-09 — — CN disclosed
WO-2022272248-A1 CBL-B MODULATORS AND USES THEREOF NIMBUS CLIO, INC. (US) 2022-12-29 — — WO disclosed
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