SCHEMBL24820137

SCHEMBL24820137

Cn1cnnc1-c1cc(Cl)ccc1-c1cc(-c2nc3cc(CO)cc(F)c3o2)nc(C2CC2)c1

nearest known ligand 0.33

Predicted protein targets (top 1)

geneUniProtsupporting neighboursconfidence
▸ CBLB Q13191 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL30152955 1.00 CBLB (0.33) CBLB
SCHEMBL24820581 0.92 CBLB (0.33) CBLB
SCHEMBL30152929 0.92 CBLB (0.33) CBLB
SCHEMBL30152733 0.89 CBLB (0.43) CBLB
SCHEMBL24818968 0.89 CBLB (0.43) CBLB
SCHEMBL24820112 0.88 CBLB (0.33) CBLB
SCHEMBL30152681 0.88 CBLB (0.33) CBLB
SCHEMBL24820738 0.87 NPC1 (0.35) CBLB
SCHEMBL24818781 0.86 CBLB (0.42) CBLB
SCHEMBL24820135 0.86 CBLB (0.33) CBLB

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-117858865-A CBL-B modulators and uses thereof 林伯士克莱奥公司 2024-04-09 — — CN disclosed
WO-2022272248-A1 CBL-B MODULATORS AND USES THEREOF NIMBUS CLIO, INC. (US) 2022-12-29 — — WO disclosed
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