Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 7/20 | 0.36 |
| ▸ | FFAR4 | Q5NUL3 | 9/20 | 0.34 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.34 |
| ▸ | RORC | P51449 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30164881 | 1.00 | EGFR (0.36) | EGFRFFAR4MAPK1RORC | |
| SCHEMBL30848775 | 0.88 | EGFR (0.39) | EGFRMAPK1RORC | |
| SCHEMBL30164839 | 0.88 | EGFR (0.39) | EGFRMAPK1RORC | |
| SCHEMBL30848793 | 0.88 | EGFR (0.39) | EGFRMAPK1 | |
| SCHEMBL24827270 | 0.88 | EGFR (0.39) | EGFRMAPK1 | |
| SCHEMBL24824604 | 0.88 | EGFR (0.39) | EGFRMAPK1RORC | |
| SCHEMBL24824597 | 0.88 | EGFR (0.39) | EGFRMAPK1RORC | |
| SCHEMBL24826154 | 0.87 | EGFR (0.38) | EGFRMAPK1 | |
| SCHEMBL30848810 | 0.87 | EGFR (0.38) | EGFRMAPK1 | |
| SCHEMBL24824609 | 0.86 | EGFR (0.40) | EGFR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-117858872-A | Heterocyclic EGFR inhibitors for the treatment of cancer | 缆图药品公司 | 2024-04-09 | — | — | CN | disclosed |
| WO-2022271612-A1 | HETEROCYCLIC EGFR INHIBITORS FOR USE IN THE TREATMENT OF CANCER | BLUEPRINT MEDICINES CORPORATION (US) | 2022-12-29 | — | — | WO | disclosed |