Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK2 | O60674 | 12/20 | 0.64 |
| ▸ | ALK | Q9UM73 | 10/20 | 0.52 |
| ▸ | INSR | P06213 | 8/20 | 0.52 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.52 |
| ▸ | NPM1 | P06748 | 7/20 | 0.51 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2482731 | 0.92 | JAK2 (0.61) | JAK2ALKINSRCYP3A4NPM1 | |
| SCHEMBL2484901 | 0.91 | JAK2 (0.77) | JAK2ALKINSRCYP3A4NPM1 | |
| SCHEMBL519718 | 0.88 | JAK2 (0.83) | JAK2ALKINSRCYP3A4NPM1 | |
| SCHEMBL519719 | 0.88 | JAK2 (0.83) | JAK2ALKINSRCYP3A4NPM1 | |
| SCHEMBL519920 | 0.88 | JAK2 (0.83) | JAK2ALKINSRCYP3A4NPM1 | |
| SCHEMBL2479887 | 0.88 | JAK2 (0.55) | JAK2ALKINSRCYP3A4NPM1 | |
| SCHEMBL520384 | 0.85 | JAK2 (0.66) | JAK2ALKINSRCYP3A4NPM1 | |
| SCHEMBL520353 | 0.83 | JAK2 (0.64) | JAK2ALKINSRCYP3A4NPM1 | |
| SCHEMBL2479373 | 0.82 | ALK (0.57) | JAK2ALKINSRCYP3A4NPM1 | |
| SCHEMBL520055 | 0.80 | JAK2 (0.81) | JAK2ALKINSRCYP3A4NPM1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2376491-A1 | PYRROLOTRIAZINES AS ALK AND JAK2 INHIBITORS | Cephalon, Inc. (US) | 2011-10-19 | — | — | EP | claimed |
| WO-2010071885-A1 | PYRROLOTRIAZINES AS ALK AND JAK2 INHIBITORS | CEPHALON, INC. (US) | 2010-06-24 | — | — | WO | claimed |