SCHEMBL2483189

SCHEMBL2483189

Cc1ccc(N2C(=O)c3cccc4c(Nc5ccc6c7c(cc(=O)n6C)-c6ccccc6C(=O)c57)ccc(c34)C2=O)c(C)c1

nearest known ligand 0.51

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
NR4A1 P22736 1/20 0.51
MAPT P10636 2/20 0.50
SMN1; SMN2 Q16637 2/20 0.50
PABPC1 P11940 1/20 0.50
MAPK1 P28482 2/20 0.48
MEN1 O00255 2/20 0.48
KMT2A Q03164 2/20 0.48
NSD2 O96028 1/20 0.48
POLB P06746 1/20 0.48
THRB P10828 1/20 0.48
S100A4 P26447 1/20 0.48
TDP1 Q9NUW8 1/20 0.48
L3MBTL1 Q9Y468 1/20 0.48
CYP1A2 P05177 2/20 0.45
ALDH1A1 P00352 1/20 0.45
LMNA P02545 1/20 0.45
ADORA2A P29274 1/20 0.45
BRD1 O95696 11/20 0.45
BRPF1 P55201 11/20 0.45
TAF1 P21675 10/20 0.45

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL12311512 0.83 NR4A1 (0.64) NR4A1MAPTSMN1; SMN2PABPC1MAPK1
SCHEMBL12311513 0.80 NR4A1 (0.62) NR4A1MAPTSMN1; SMN2PABPC1MAPK1
SCHEMBL13316765 0.77 NR4A1 (0.61) NR4A1MAPTSMN1; SMN2PABPC1MAPK1
SCHEMBL14395665 0.77 MAPT (0.60) NR4A1MAPTSMN1; SMN2PABPC1MAPK1
SCHEMBL12311509 0.76 NR4A1 (0.62) NR4A1MAPTSMN1; SMN2PABPC1MAPK1
SCHEMBL12311506 0.76 NR4A1 (0.69) NR4A1MAPTSMN1; SMN2PABPC1MAPK1
SCHEMBL29384913 0.76 NR4A1 (0.78) NR4A1MAPTSMN1; SMN2PABPC1MAPK1
SCHEMBL305199 0.76 NR4A1 (0.78) NR4A1MAPTSMN1; SMN2PABPC1MAPK1
SCHEMBL12311514 0.76 NR4A1 (0.65) NR4A1MAPTSMN1; SMN2PABPC1MAPK1
SCHEMBL14283332 0.74 NR4A1 (0.62) NR4A1MAPTSMN1; SMN2PABPC1MAPK1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2057123-B1 ANTHRAPYRIDONE COMPOUNDS SABIC INNOVATIVE PLASTICS IP (NL) 2011-10-19 EP disclosed
EP-2057123-B1 ANTHRAPYRIDONE COMPOUNDS SABIC INNOVATIVE PLASTICS IP (NL) 2011-10-19 EP disclosed
US-7812076-B2 Anthrapyridone compounds SABIC INNOVATIVE PLASTICS IP B.V. (NL) 2010-10-12 US disclosed
US-7812076-B2 Anthrapyridone compounds SABIC INNOVATIVE PLASTICS IP B.V. (NL) 2010-10-12 US disclosed
US-7812076-B2 Anthrapyridone compounds SABIC INNOVATIVE PLASTICS IP B.V. (NL) 2010-10-12 US disclosed
EP-2057123-A1 ANTHRAPYRIDONE COMPOUNDS Sabic Innovative Plastics IP B.V. (NL) 2009-05-13 EP disclosed
US-20080045634-A1 ANTHRAPYRIDONE COMPOUNDS GENERAL ELECTRIC COMPANY (US) 2008-02-21 US disclosed
US-20080045634-A1 ANTHRAPYRIDONE COMPOUNDS GENERAL ELECTRIC COMPANY (US) 2008-02-21 US disclosed
US-20080045634-A1 ANTHRAPYRIDONE COMPOUNDS GENERAL ELECTRIC COMPANY (US) 2008-02-21 US disclosed
WO-2008021694-A1 ANTHRAPYRIDONE COMPOUNDS SABIC INNOVATIVE PLASTICS IP B.V. (NL) 2008-02-21 WO disclosed
WO-2008021694-A1 ANTHRAPYRIDONE COMPOUNDS SABIC INNOVATIVE PLASTICS IP B.V. (NL) 2008-02-21 WO disclosed