Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRM3 | P20309 | 18/20 | 0.42 |
| ▸ | CHRM2 | P08172 | 10/20 | 0.42 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.40 |
| ▸ | CHRM1 | P11229 | 5/20 | 0.38 |
| ▸ | PDE2A | O00408 | 2/20 | 0.37 |
| ▸ | PDE6D | O43924 | 2/20 | 0.37 |
| ▸ | PDE8A | O60658 | 2/20 | 0.37 |
| ▸ | PDE5A | O76074 | 2/20 | 0.37 |
| ▸ | PDE9A | O76083 | 2/20 | 0.37 |
| ▸ | PDE8B | O95263 | 2/20 | 0.37 |
| ▸ | PDE6A | P16499 | 2/20 | 0.37 |
| ▸ | PDE6G | P18545 | 2/20 | 0.37 |
| ▸ | PDE4A | P27815 | 2/20 | 0.37 |
| ▸ | PDE6B | P35913 | 2/20 | 0.37 |
| ▸ | PDE6C | P51160 | 2/20 | 0.37 |
| ▸ | PDE1A | P54750 | 2/20 | 0.37 |
| ▸ | PDE1B | Q01064 | 2/20 | 0.37 |
| ▸ | PDE4B | Q07343 | 2/20 | 0.37 |
| ▸ | PDE4C | Q08493 | 2/20 | 0.37 |
| ▸ | PDE4D | Q08499 | 2/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14996177 | 0.96 | CHRM3 (0.45) | CHRM3CHRM2NPSR1CHRM1PDE2A | |
| Trifluoroacetic Acid SCHEMBL2984440 | 0.94 | CHRM3 (0.40) | CHRM3CHRM2NPSR1CHRM1PDE2A | |
| SCHEMBL12072370 | 0.93 | CHRM3 (0.45) | CHRM3CHRM2NPSR1CHRM1 | |
| SCHEMBL15127395 | 0.93 | CHRM3 (0.45) | CHRM3CHRM2NPSR1CHRM1 | |
| Trifluoroacetic Acid SCHEMBL2487109 | 0.92 | CHRM3 (0.39) | CHRM3CHRM2NPSR1CHRM1PDE2A | |
| Bromide SCHEMBL15117688 | 0.92 | CHRM3 (0.46) | CHRM3CHRM2NPSR1CHRM1 | |
| Trifluoroacetic Acid SCHEMBL2998194 | 0.91 | CHRM3 (0.41) | CHRM3CHRM2NPSR1CHRM1PDE2A | |
| Trifluoroacetic Acid SCHEMBL2983221 | 0.90 | CHRM3 (0.38) | CHRM3CHRM2NPSR1CHRM1PDE2A | |
| Trifluoroacetic Acid SCHEMBL15117534 | 0.90 | CHRM3 (0.39) | CHRM3CHRM2NPSR1CHRM1PDE2A | |
| Trifluoroacetic Acid SCHEMBL2996006 | 0.89 | CHRM3 (0.41) | CHRM3CHRM2NPSR1CHRM1PDE2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2376489-B1 | ALKALOID AMINOESTER DERIVATIVES AND MEDICINAL COMPOSITION THEREOF | CHIESI FARMA SPA (IT) | 2015-04-22 | — | — | EP | claimed |
| US-8455646-B2 | Alkaloid aminoester derivatives and medicinal composition thereof | CHIESI FARMACEUTICI S.P.A. (IT) | 2013-06-04 | — | — | US | claimed |
| EP-2376489-A1 | Alkaloid aminoester derivatives and medicinal composition thereof | Chiesi Farmaceutici S.p.A. (IT) | 2011-10-19 | — | — | EP | claimed |
| US-20100173880-A1 | ALKALOID AMINOESTER DERIVATIVES AND MEDICINAL COMPOSITION THEREOF | CHIESI FARMACEUTICI S.P.A. (IT) | 2010-07-08 | — | — | US | claimed |
| WO-2010072338-A1 | ALKALOID AMINOESTER DERIVATIVES AND MEDICINAL COMPOSITION THEREOF | CHIESI FARMACEUTICI S.P.A. (IT) | 2010-07-01 | — | — | WO | claimed |
| EP-2376489-B1 | ALKALOID AMINOESTER DERIVATIVES AND MEDICINAL COMPOSITION THEREOF | CHIESI FARMA SPA (IT) | 2015-04-22 | — | — | EP | disclosed |
| US-20130196978-A1 | ALKALOID AMINOESTER DERIVATIVES AND MEDICINAL COMPOSITION THEREOF | CHIESI FARMACEUTICI S.P.A. (IT) | 2013-08-01 | — | — | US | disclosed |
| US-8455646-B2 | Alkaloid aminoester derivatives and medicinal composition thereof | CHIESI FARMACEUTICI S.P.A. (IT) | 2013-06-04 | — | — | US | disclosed |
| US-20100173880-A1 | ALKALOID AMINOESTER DERIVATIVES AND MEDICINAL COMPOSITION THEREOF | CHIESI FARMACEUTICI S.P.A. (IT) | 2010-07-08 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20130196978-A1 | ALKALOID AMINOESTER DERIVATIVES AND MEDICINAL COMPOSITION THEREOF | CHRM3, CHRM1, CHRNG | CHRM3 1/4885CHRM2 4/4885NPSR1 632/4885 |
| US-20100173880-A1 | ALKALOID AMINOESTER DERIVATIVES AND MEDICINAL COMPOSITION THEREOF | CHRM3, CHRM1, CHRNG | CHRM3 1/4885CHRM2 4/4885NPSR1 632/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.