Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MTOR | P42345 | 2/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.34 |
| ▸ | GAA | P10253 | 1/20 | 0.34 |
| ▸ | MEN1 | O00255 | 3/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.34 |
| ▸ | MAPT | P10636 | 2/20 | 0.34 |
| ▸ | OPRM1 | P35372 | 2/20 | 0.33 |
| ▸ | OPRD1 | P41143 | 2/20 | 0.33 |
| ▸ | OGFRL1 | Q5TC84 | 2/20 | 0.33 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.33 |
| ▸ | PARP1 | P09874 | 1/20 | 0.33 |
| ▸ | TNKS2 | Q9H2K2 | 1/20 | 0.33 |
| ▸ | PARP2 | Q9UGN5 | 1/20 | 0.33 |
| ▸ | ATM | Q13315 | 1/20 | 0.33 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.33 |
| ▸ | ABL1 | P00519 | 1/20 | 0.33 |
| ▸ | RIN1 | Q13671 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27191286 | 1.00 | MTOR (0.39) | MTORHPGDEPHX1ALDH1A1SMN1; SMN2 | |
| SCHEMBL30118094 | 1.00 | MTOR (0.39) | MTORHPGDEPHX1ALDH1A1SMN1; SMN2 | |
| SCHEMBL29182037 | 1.00 | MTOR (0.39) | MTORHPGDEPHX1ALDH1A1SMN1; SMN2 | |
| SCHEMBL444134 | 0.83 | MTOR (0.55) | MTORPIK3R1PIK3CA | |
| SCHEMBL444716 | 0.83 | MTOR (0.55) | MTORPIK3R1PIK3CA | |
| SCHEMBL412835 | 0.83 | MTOR (0.55) | MTORPIK3R1PIK3CA | |
| SCHEMBL25265824 | 0.83 | MTOR (0.38) | MTORHPGDALDH1A1MEN1KMT2A | |
| SCHEMBL25196466 | 0.83 | MTOR (0.38) | MTORHPGDALDH1A1MEN1KMT2A | |
| SCHEMBL20589400 | 0.83 | MTOR (0.38) | MTORHPGDALDH1A1MEN1KMT2A | |
| SCHEMBL19358215 | 0.82 | MTOR (0.46) | MTORHPGDSMN1; SMN2MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-117769554-A | Small molecule inhibitors of KRAS muteins | 大鹏药品工业株式会社 | 2024-03-26 | — | — | CN | disclosed |
| WO-2022250170-A9 | SMALL MOLECULE INHIBITORS OF KRAS MUTATED PROTEINS | TAIHO PHARMACEUTICAL CO., LTD. (JP) | 2023-01-05 | — | — | WO | disclosed |