Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CCR2 | P41597 | 4/20 | 0.41 |
| ▸ | KCNH2 | Q12809 | 3/20 | 0.41 |
| ▸ | SCD5 | Q86SK9 | 1/20 | 0.40 |
| ▸ | NAMPT | P43490 | 1/20 | 0.40 |
| ▸ | SPR | P35270 | 1/20 | 0.39 |
| ▸ | DGAT2 | Q96PD7 | 6/20 | 0.39 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.38 |
| ▸ | RORC | P51449 | 5/20 | 0.37 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2389867 | 0.83 | NAMPT (0.48) | CCR2KCNH2SCD5NAMPTSPR | |
| SCHEMBL12255760 | 0.81 | NAMPT (0.46) | CCR2KCNH2SCD5NAMPTSPR | |
| SCHEMBL2485619 | 0.81 | ALOX5AP (0.46) | CCR2KCNH2SCD5NAMPTSPR | |
| SCHEMBL2390969 | 0.75 | NAMPT (0.59) | CCR2KCNH2NAMPTSPR | |
| SCHEMBL2390771 | 0.74 | NAMPT (0.54) | CCR2KCNH2SCD5NAMPTSPR | |
| SCHEMBL14670316 | 0.73 | NAMPT (0.52) | SCD5NAMPTSPRTDP1 | |
| SCHEMBL2390273 | 0.72 | NAMPT (0.52) | CCR2KCNH2SCD5NAMPTSPR | |
| SCHEMBL2389262 | 0.72 | NAMPT (0.53) | CCR2KCNH2SCD5NAMPTSPR | |
| SCHEMBL2391621 | 0.71 | NAMPT (0.57) | CCR2KCNH2SCD5NAMPTSPR | |
| SCHEMBL2390754 | 0.71 | NAMPT (0.56) | SCD5NAMPTSPRRORC |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2375904-A1 | BIARYL CARBOXAMIDES | Merck Sharp & Dohme Corp. (US) | 2011-10-19 | — | — | EP | disclosed |
| WO-2010077624-A1 | BIARYL CARBOXAMIDES | MERCK SHARP & DOHME CORP. (US) | 2010-07-08 | — | — | WO | disclosed |