Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMARCA2 | P51531 | 2/20 | 0.46 |
| ▸ | SMARCA4 | P51532 | 2/20 | 0.46 |
| ▸ | PBRM1 | Q86U86 | 2/20 | 0.46 |
| ▸ | PARP1 | P09874 | 2/20 | 0.40 |
| ▸ | PRKCG | P05129 | 1/20 | 0.36 |
| ▸ | PRKCB | P05771 | 1/20 | 0.36 |
| ▸ | PRKCA | P17252 | 1/20 | 0.36 |
| ▸ | PRKCH | P24723 | 1/20 | 0.36 |
| ▸ | PRKCE | Q02156 | 1/20 | 0.36 |
| ▸ | PRKCD | Q05655 | 1/20 | 0.36 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.36 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.36 |
| ▸ | OGFRL1 | Q5TC84 | 1/20 | 0.36 |
| ▸ | ACACB | O00763 | 1/20 | 0.35 |
| ▸ | ACACA | Q13085 | 1/20 | 0.35 |
| ▸ | PIM1 | P11309 | 1/20 | 0.35 |
| ▸ | PIM2 | Q9P1W9 | 1/20 | 0.35 |
| ▸ | GPR119 | Q8TDV5 | 3/20 | 0.34 |
| ▸ | STS | P08842 | 1/20 | 0.34 |
| ▸ | CCNT1 | O60563 | 2/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30179121 | 1.00 | SMARCA2 (0.46) | SMARCA2SMARCA4PBRM1PARP1PRKCG | |
| SCHEMBL30179227 | 1.00 | SMARCA2 (0.46) | SMARCA2SMARCA4PBRM1PARP1PRKCG | |
| SCHEMBL30178884 | 1.00 | SMARCA2 (0.46) | SMARCA2SMARCA4PBRM1PARP1PRKCG | |
| SCHEMBL30178957 | 1.00 | SMARCA2 (0.46) | SMARCA2SMARCA4PBRM1PARP1PRKCG | |
| SCHEMBL24838421 | 1.00 | SMARCA2 (0.46) | SMARCA2SMARCA4PBRM1PARP1PRKCG | |
| SCHEMBL24838350 | 1.00 | SMARCA2 (0.46) | SMARCA2SMARCA4PBRM1PARP1PRKCG | |
| SCHEMBL24838437 | 1.00 | SMARCA2 (0.46) | SMARCA2SMARCA4PBRM1PARP1PRKCG | |
| SCHEMBL24838737 | 1.00 | SMARCA2 (0.46) | SMARCA2SMARCA4PBRM1PARP1PRKCG | |
| SCHEMBL24837891 | 0.98 | SMARCA2 (0.45) | SMARCA2SMARCA4PBRM1PARP1PRKCG | |
| SCHEMBL24838750 | 0.98 | SMARCA2 (0.45) | SMARCA2SMARCA4PBRM1PARP1PRKCG |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023239645-A1 | SMARCA DEGRADERS AND USES THEREOF | KYMERA THERAPEUTICS, INC. (US) | 2023-12-14 | — | — | WO | disclosed |
| US-20230173078-A1 | SMARCA DEGRADERS AND USES THEREOF | KYMERA THERAPEUTICS, INC. | 2023-06-08 | — | — | US | disclosed |
| US-20230173078-A1 | SMARCA DEGRADERS AND USES THEREOF | KYMERA THERAPEUTICS, INC. | 2023-06-08 | — | — | US | disclosed |
| WO-2023278402-A1 | SMARCA DEGRADERS AND USES THEREOF | KYMERA THERAPEUTICS, INC. (US) | 2023-01-05 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20230173078-A1 | SMARCA DEGRADERS AND USES THEREOF | SMARCA1, SMARCA2, SMARCC2 | SMARCA2 2/4885SMARCA4 8/4885PBRM1 126/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.