Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH3 | Q9Y5N1 | 7/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.40 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.40 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.38 |
| ▸ | TSHR | P16473 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | CNR1 | P21554 | 1/20 | 0.37 |
| ▸ | CNR2 | P34972 | 1/20 | 0.37 |
| ▸ | TP53 | P04637 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25605834 | 0.87 | HRH3 (0.40) | HRH3KDM4ECYP2C9CYP2C19ALDH1A1 | |
| SCHEMBL25631008 | 0.87 | HRH3 (0.40) | HRH3KDM4ECYP2C9CYP2C19ALDH1A1 | |
| SCHEMBL25029561 | 0.81 | NPC1 (0.43) | KDM4ECYP2C9CYP2C19KMT2A | |
| SCHEMBL25029687 | 0.78 | NPC1 (0.40) | HRH3KDM4ECYP2C9CYP2C19ALDH1A1 | |
| SCHEMBL12197897 | 0.74 | PIK3CD (0.55) | KDM4EALDH1A1L3MBTL1KMT2ACNR1 | |
| SCHEMBL25075074 | 0.73 | HRH3 (0.44) | HRH3KDM4EALDH1A1 | |
| SCHEMBL25600556 | 0.73 | CNR1 (0.34) | HRH3KDM4ECYP2C9CYP2C19ALDH1A1 | |
| SCHEMBL25600554 | 0.73 | CNR1 (0.34) | HRH3KDM4ECYP2C9CYP2C19ALDH1A1 | |
| SCHEMBL25631005 | 0.72 | KDM4E (0.52) | KDM4ECYP2C9CYP2C19ALDH1A1L3MBTL1 | |
| SCHEMBL25631004 | 0.72 | KDM4E (0.52) | KDM4ECYP2C9CYP2C19ALDH1A1L3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023278402-A1 | SMARCA DEGRADERS AND USES THEREOF | KYMERA THERAPEUTICS, INC. (US) | 2023-01-05 | — | — | WO | disclosed |