Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRM3 | P20309 | 15/20 | 0.52 |
| ▸ | PDE4B | Q07343 | 7/20 | 0.51 |
| ▸ | PDE2A | O00408 | 3/20 | 0.51 |
| ▸ | PDE6D | O43924 | 3/20 | 0.51 |
| ▸ | PDE8A | O60658 | 3/20 | 0.51 |
| ▸ | PDE5A | O76074 | 3/20 | 0.51 |
| ▸ | PDE9A | O76083 | 3/20 | 0.51 |
| ▸ | PDE8B | O95263 | 3/20 | 0.51 |
| ▸ | PDE6A | P16499 | 3/20 | 0.51 |
| ▸ | PDE6G | P18545 | 3/20 | 0.51 |
| ▸ | PDE4A | P27815 | 3/20 | 0.51 |
| ▸ | PDE6B | P35913 | 3/20 | 0.51 |
| ▸ | PDE6C | P51160 | 3/20 | 0.51 |
| ▸ | PDE1A | P54750 | 3/20 | 0.51 |
| ▸ | PDE1B | Q01064 | 3/20 | 0.51 |
| ▸ | PDE4C | Q08493 | 3/20 | 0.51 |
| ▸ | PDE4D | Q08499 | 3/20 | 0.51 |
| ▸ | PDE3B | Q13370 | 3/20 | 0.51 |
| ▸ | PDE7A | Q13946 | 3/20 | 0.51 |
| ▸ | PDE6H | Q13956 | 3/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13240815 | 1.00 | CHRM3 (0.52) | CHRM3PDE4BPDE2APDE6DPDE8A | |
| SCHEMBL13240795 | 0.89 | CHRM3 (0.56) | CHRM3PDE4BPDE2APDE6DPDE8A | |
| SCHEMBL2509819 | 0.89 | CHRM3 (0.56) | CHRM3PDE4BPDE2APDE6DPDE8A | |
| SCHEMBL13240838 | 0.86 | CHRM3 (0.53) | CHRM3PDE4BPDE2APDE6DPDE8A | |
| SCHEMBL2512271 | 0.86 | CHRM3 (0.53) | CHRM3PDE4BPDE2APDE6DPDE8A | |
| SCHEMBL19894881 | 0.85 | CHRM3 (0.57) | CHRM3PDE4BPDE2APDE6DPDE8A | |
| SCHEMBL13240852 | 0.84 | CHRNA7 (0.53) | CHRM3PDE4BPDE2APDE6DPDE8A | |
| SCHEMBL19894936 | 0.81 | CHRM3 (0.51) | CHRM3PDE4BPDE2APDE6DPDE8A | |
| SCHEMBL1695924 | 0.81 | CHRM3 (0.58) | CHRM3CHRNA7BCHEACHECHRM2 | |
| SCHEMBL1695927 | 0.81 | CHRM3 (0.58) | CHRM3CHRNA7BCHEACHECHRM2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2376489-A1 | Alkaloid aminoester derivatives and medicinal composition thereof | Chiesi Farmaceutici S.p.A. (IT) | 2011-10-19 | — | — | EP | disclosed |