Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK3 | P52333 | 17/20 | 0.43 |
| ▸ | JAK1 | P23458 | 17/20 | 0.43 |
| ▸ | JAK2 | O60674 | 16/20 | 0.43 |
| ▸ | TYK2 | P29597 | 2/20 | 0.43 |
| ▸ | CNR2 | P34972 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2378169 | 0.86 | JAK3 (0.38) | JAK3JAK1JAK2TYK2CNR2 | |
| SCHEMBL2379421 | 0.86 | JAK3 (0.40) | JAK3JAK1JAK2TYK2CNR2 | |
| SCHEMBL2378332 | 0.84 | JAK3 (0.41) | JAK3JAK1JAK2TYK2CNR2 | |
| SCHEMBL2378268 | 0.84 | JAK1 (0.40) | JAK3JAK1JAK2TYK2CNR2 | |
| SCHEMBL2378414 | 0.82 | JAK3 (0.39) | JAK3JAK1JAK2TYK2CNR2 | |
| SCHEMBL14751953 | 0.79 | JAK2 (0.53) | JAK3JAK1JAK2TYK2 | |
| SCHEMBL2377922 | 0.77 | JAK1 (0.39) | JAK3JAK1JAK2TYK2 | |
| SCHEMBL2379093 | 0.77 | JAK2 (0.45) | JAK3JAK1JAK2TYK2CNR2 | |
| SCHEMBL2379097 | 0.77 | JAK2 (0.45) | JAK3JAK1JAK2TYK2CNR2 | |
| SCHEMBL14751009 | 0.76 | CNR2 (0.34) | JAK3JAK1JAK2TYK2CNR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2550273-A2 | PYRROLOPYRAZINE KINASE INHIBITORS | F. Hoffmann-La Roche AG (CH) | 2013-01-30 | — | — | EP | disclosed |
| WO-2011117145-A2 | PYRROLOPYRAZINE KINASE INHIBITORS | F. HOFFMANN-LA ROCHE AG (CH) | 2011-09-29 | — | — | WO | disclosed |