Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK2 | O60674 | 6/20 | 0.61 |
| ▸ | JAK1 | P23458 | 5/20 | 0.61 |
| ▸ | TYK2 | P29597 | 5/20 | 0.61 |
| ▸ | JAK3 | P52333 | 5/20 | 0.61 |
| ▸ | STAT3 | P40763 | 1/20 | 0.61 |
| ▸ | MAP3K14 | Q99558 | 1/20 | 0.51 |
| ▸ | BTK | Q06187 | 8/20 | 0.47 |
| ▸ | MAPK1 | P28482 | 5/20 | 0.47 |
| ▸ | MAPK3 | P27361 | 3/20 | 0.47 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.44 |
| ▸ | HRH2 | P25021 | 1/20 | 0.44 |
| ▸ | CDK7 | P50613 | 1/20 | 0.44 |
| ▸ | CD69 | Q07108 | 1/20 | 0.44 |
| ▸ | AAK1 | Q2M2I8 | 1/20 | 0.44 |
| ▸ | MAP3K19 | Q56UN5 | 1/20 | 0.44 |
| ▸ | CDKL2 | Q92772 | 1/20 | 0.44 |
| ▸ | RIOK1 | Q9BRS2 | 1/20 | 0.44 |
| ▸ | RIOK2 | Q9BVS4 | 1/20 | 0.44 |
| ▸ | BMP2K | Q9NSY1 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27452008 | 0.85 | JAK1 (0.51) | JAK2JAK1TYK2JAK3STAT3 | |
| SCHEMBL27452000 | 0.83 | JAK1 (0.47) | JAK2JAK1TYK2JAK3STAT3 | |
| SCHEMBL23275720 | 0.81 | JAK2 (0.64) | JAK2JAK1TYK2JAK3STAT3 | |
| SCHEMBL23275663 | 0.80 | JAK2 (0.68) | JAK2JAK1TYK2JAK3STAT3 | |
| SCHEMBL18897787 | 0.79 | JAK2 (0.69) | JAK2JAK1TYK2JAK3STAT3 | |
| SCHEMBL27228445 | 0.78 | JAK3 (0.76) | JAK2JAK1TYK2JAK3STAT3 | |
| SCHEMBL23281883 | 0.78 | JAK2 (0.60) | JAK2JAK1TYK2JAK3STAT3 | |
| SCHEMBL23275741 | 0.76 | JAK2 (0.59) | JAK2JAK1TYK2JAK3STAT3 | |
| SCHEMBL23275721 | 0.76 | JAK2 (0.52) | JAK2JAK1TYK2JAK3STAT3 | |
| SCHEMBL23275844 | 0.76 | JAK2 (0.52) | JAK2JAK1TYK2JAK3STAT3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20230002362-A1 | BENZAMIDES OF PYRAZOLYLAMINO- PYRIMIDINYL DERIVATIVES, AND COMPOSITIONS AND METHODS THEREOF | LYNK PHARMACEUTICALS CO. LTD. (CN) | 2023-01-05 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20230002362-A1 | BENZAMIDES OF PYRAZOLYLAMINO- PYRIMIDINYL DERIVATIVES, AND COMPOSITIONS AND METHODS THEREOF | JAK1, JAK3, JAK2 | JAK2 3/4885JAK1 1/4885TYK2 17/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.