Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 7/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.46 |
| ▸ | RAB9A | P51151 | 6/20 | 0.46 |
| ▸ | NPC1 | O15118 | 6/20 | 0.46 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.46 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.41 |
| ▸ | NFKB1 | P19838 | 2/20 | 0.41 |
| ▸ | NFKB2 | Q00653 | 2/20 | 0.41 |
| ▸ | RELA | Q04206 | 2/20 | 0.41 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.41 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.41 |
| ▸ | ADORA2B | P29275 | 1/20 | 0.41 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.41 |
| ▸ | TSHR | P16473 | 4/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.40 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.40 |
| ▸ | IRAK4 | Q9NWZ3 | 2/20 | 0.39 |
| ▸ | NMT2 | O60551 | 1/20 | 0.39 |
| ▸ | NMT1 | P30419 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18341454 | 0.81 | NPSR1 (0.45) | SMN1; SMN2ALDH1A1RAB9ANPC1L3MBTL1 | |
| SCHEMBL1521991 | 0.81 | IRAK4 (0.53) | SMN1; SMN2ALDH1A1RAB9ANPC1L3MBTL1 | |
| SCHEMBL29709769 | 0.81 | NPSR1 (0.45) | SMN1; SMN2ALDH1A1RAB9ANPC1L3MBTL1 | |
| SCHEMBL29709761 | 0.81 | IRAK4 (0.53) | SMN1; SMN2ALDH1A1RAB9ANPC1L3MBTL1 | |
| SCHEMBL1521897 | 0.76 | NPC1 (0.40) | SMN1; SMN2ALDH1A1RAB9ANPC1L3MBTL1 | |
| SCHEMBL16878927 | 0.71 | IRAK4 (0.49) | SMN1; SMN2ALDH1A1RAB9ANPC1L3MBTL1 | |
| SCHEMBL15688990 | 0.70 | IRAK4 (0.51) | SMN1; SMN2ALDH1A1RAB9ANPC1L3MBTL1 | |
| SCHEMBL16873155 | 0.70 | IRAK4 (0.51) | SMN1; SMN2ALDH1A1RAB9ANPC1L3MBTL1 | |
| SCHEMBL16884064 | 0.70 | IRAK4 (0.51) | SMN1; SMN2ALDH1A1RAB9ANPC1L3MBTL1 | |
| SCHEMBL15714840 | 0.69 | IRAK4 (0.53) | SMN1; SMN2ALDH1A1RAB9ANPC1L3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20230000871-A1 | GEM-DISUBSTITUTED HETEROCYCLIC COMPOUNDS AND THEIR USE AS IDH INHIBITORS | NERVIANO MEDICAL SCIENCES S.R.L. (IT) | 2023-01-05 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20230000871-A1 | GEM-DISUBSTITUTED HETEROCYCLIC COMPOUNDS AND THEIR USE AS IDH INHIBITORS | IDH1, IDH2, IDH3A | SMN1; SMN2 1183/4885ALDH1A1 478/4885RAB9A 2078/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.