Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CDK4 | P11802 | 7/20 | 0.49 |
| ▸ | CCND1 | P24385 | 7/20 | 0.49 |
| ▸ | CCND2 | P30279 | 4/20 | 0.49 |
| ▸ | CCND3 | P30281 | 4/20 | 0.49 |
| ▸ | CDK2 | P24941 | 4/20 | 0.44 |
| ▸ | CCNE1 | P24864 | 3/20 | 0.44 |
| ▸ | CCNT1 | O60563 | 2/20 | 0.44 |
| ▸ | CDK9 | P50750 | 2/20 | 0.44 |
| ▸ | CDK6 | Q00534 | 2/20 | 0.44 |
| ▸ | MAPK8 | P45983 | 12/20 | 0.44 |
| ▸ | AURKA | O14965 | 1/20 | 0.43 |
| ▸ | LIMK1 | P53667 | 1/20 | 0.43 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.43 |
| ▸ | MAPK10 | P53779 | 10/20 | 0.42 |
| ▸ | MAPK9 | P45984 | 7/20 | 0.42 |
| ▸ | CCNA2 | P20248 | 2/20 | 0.40 |
| ▸ | CCNB2 | O95067 | 1/20 | 0.40 |
| ▸ | CCNE2 | O96020 | 1/20 | 0.40 |
| ▸ | CDK1 | P06493 | 1/20 | 0.40 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20710554 | 0.79 | CDK4 (0.54) | CDK4CCND1CCND2CCND3CDK2 | |
| SCHEMBL23142003 | 0.72 | CDK4 (0.53) | CDK4CCND1CCND2CCND3CDK2 | |
| SCHEMBL29990571 | 0.72 | CDK4 (0.53) | CDK4CCND1CCND2CCND3CDK2 | |
| SCHEMBL25463635 | 0.71 | CDK4 (0.58) | CDK4CCND1CCND2CCND3CDK2 | |
| SCHEMBL24669972 | 0.71 | CDK4 (0.69) | CDK4CCND1CCND2CCND3CDK2 | |
| SCHEMBL4825502 | 0.70 | CDK4 (0.57) | CDK4CCND1CCND2CCND3CDK2 | |
| SCHEMBL24856132 | 0.70 | CDK4 (0.57) | CDK4CCND1CCND2CCND3CDK2 | |
| SCHEMBL5266289 | 0.70 | CDK4 (0.57) | CDK4CCND1CCND2CCND3CDK2 | |
| SCHEMBL31267089 | 0.69 | ATM (0.32) | — | |
| SCHEMBL30872647 | 0.68 | CDK2 (0.50) | CDK4CCND1CCND3CDK2CCNE1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20230000871-A1 | GEM-DISUBSTITUTED HETEROCYCLIC COMPOUNDS AND THEIR USE AS IDH INHIBITORS | NERVIANO MEDICAL SCIENCES S.R.L. (IT) | 2023-01-05 | — | — | US | disclosed |
| CN-115038700-A | Gem disubstituted heterocyclic compounds and their use as IDH inhibitors | 内尔维亚诺医疗科学公司 | 2022-09-09 | — | — | CN | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20230000871-A1 | GEM-DISUBSTITUTED HETEROCYCLIC COMPOUNDS AND THEIR USE AS IDH INHIBITORS | IDH1, IDH2, IDH3A | CDK4 444/4885CCND1 1448/4885CCND2 1009/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.