Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Bicarbonate. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA1 | P00915 | 1/20 | 0.83 |
| ▸ | CA2 | P00918 | 1/20 | 0.83 |
| ▸ | CA9 | Q16790 | 1/20 | 0.83 |
| ▸ | FFAR3 | O14843 | 2/20 | 0.44 |
| ▸ | ACHE | P22303 | 1/20 | 0.44 |
| ▸ | LCK | P06239 | 1/20 | 0.44 |
| ▸ | FYN | P06241 | 1/20 | 0.44 |
| ▸ | TSHR | P16473 | 4/20 | 0.36 |
| ▸ | LMNA | P02545 | 3/20 | 0.36 |
| ▸ | LDHA | P00338 | 2/20 | 0.36 |
| ▸ | EGLN1 | Q9GZT9 | 2/20 | 0.36 |
| ▸ | LDHB | P07195 | 1/20 | 0.36 |
| ▸ | SRR | Q9GZT4 | 1/20 | 0.36 |
| ▸ | TP53 | P04637 | 1/20 | 0.36 |
| ▸ | ALKBH5 | Q6P6C2 | 1/20 | 0.36 |
| ▸ | SUCNR1 | Q9BXA5 | 1/20 | 0.36 |
| ▸ | EGLN3 | Q9H6Z9 | 1/20 | 0.36 |
| ▸ | OR51E2 | Q9H255 | 2/20 | 0.33 |
| ▸ | GLRA1 | P23415 | 1/20 | 0.33 |
| ▸ | SLC6A9 | P48067 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Bicarbonate SCHEMBL28455789 | 1.00 | — | — | |
| Bicarbonate SCHEMBL9274418 | 1.00 | — | — | |
| Bicarbonate SCHEMBL40505 | 1.00 | — | — | |
| Bicarbonate SCHEMBL72938 | 0.93 | — | — | |
| Bicarbonate SCHEMBL22476040 | 0.93 | CA1 (0.71) | CA1CA2CA9FFAR3ACHE | |
| Bicarbonate SCHEMBL153475 | 0.93 | CA1 (0.71) | CA1CA2CA9FFAR3ACHE | |
| Bicarbonate SCHEMBL150901 | 0.93 | — | — | |
| Bicarbonate SCHEMBL21815628 | 0.93 | — | — | |
| Bicarbonate SCHEMBL2487509 | 0.93 | CA1 (0.71) | CA1CA2CA9FFAR3ACHE | |
| Bicarbonate SCHEMBL150637 | 0.93 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-108530289-A | A kind of preparation method of lanthanum acetate | 乐山沃耐稀电子材料有限公司 | 2018-09-14 | — | — | CN | disclosed |
| EP-2645995-A1 | CAPSULE AND POWDER FORMULATIONS CONTAINING LANTHANUM COMPOUNDS | Shire LLC (US) | 2013-10-09 | — | — | EP | disclosed |
| WO-2012075194-A1 | CAPSULE AND POWDER FORMULATIONS CONTAINING LANTHANUM COMPOUNDS | SHIRE LLC (US) | 2012-06-07 | — | — | WO | disclosed |
| EP-1852695-B1 | Assay for lanthanum hydroxy carbonate | SHIRE INT LICENSING BV (NL) | 2011-10-26 | — | — | EP | disclosed |
| US-20100092576-A1 | PHARMACEUTICAL COMPOSITIONS CONTAINING LANTHANUM HYDROXYCARBONATE | SHIRE INTERNATIONAL LICENSING B.V. (NL) | 2010-04-15 | — | — | US | disclosed |
| US-7618656-B2 | Method for use of lanthanum carbonate pharmaceutical compositions | SHIRE INTERNATIONAL LICENSING B.V. (NL) | 2009-11-17 | — | — | US | disclosed |
| US-20080089948-A1 | METHOD OF USE FOR LANTHANUM CARBONATE AND LANTHANUM HYDROXYCARBONATE | SHIRE INTERNATIONAL LICENSING B.V. (NL) | 2008-04-17 | — | — | US | disclosed |
| WO-2007130721-A2 | ASSAY FOR LANTHANUM HYDROXYCARBONATE | SHIRE INTERNATIONAL LICENSING B.V. (NL) | 2007-11-15 | — | — | WO | disclosed |
| US-20070259052-A1 | Assay for lanthanum hydroxycarbonate | SHIRE INTERNATIONAL LICENSING B.V. (NL) | 2007-11-08 | — | — | US | disclosed |
| EP-1852695-A1 | Assay for lanthanum hydroxy carbonate | Shire International Licensing B.V. (NL) | 2007-11-07 | — | — | EP | disclosed |