⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30695254 | 0.87 | — | — | |
| SCHEMBL29071028 | 0.86 | — | — | |
| SCHEMBL25601390 | 0.83 | — | — | |
| SCHEMBL29071015 | 0.81 | — | — | |
| SCHEMBL25399389 | 0.80 | — | — | |
| SCHEMBL26317673 | 0.79 | — | — | |
| SCHEMBL21550615 | 0.74 | — | — | |
| SCHEMBL30699826 | 0.73 | — | — | |
| SCHEMBL29070967 | 0.72 | — | — | |
| SCHEMBL26598193 | 0.72 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 13 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4635958-A1 | PYRIMIDINE-CONTAINING POLYCYCLIC DERIVATIVE INHIBITOR, AND PREPARATION METHOD THEREFOR AND USE THEREOF | Shanghai Hansoh Biomedical Co., Ltd. (CN) | 2025-10-22 | — | — | EP | disclosed |
| US-20250042919-A1 | TETRACYCLIC OXAZEPINE COMPOUNDS AND USES THEREOF | GENENTECH, INC. (US) | 2025-02-06 | — | — | US | disclosed |
| US-20240327425-A1 | KRAS G12D INHIBITOR AND USE THEREOF | Shanghai De Novo Pharmatech Co., Ltd. (CN) | 2024-10-03 | — | — | US | disclosed |
| WO-2024125642-A1 | PYRIMIDINE-CONTAINING POLYCYCLIC DERIVATIVE INHIBITOR, AND PREPARATION METHOD THEREFOR AND USE THEREOF | 上海翰森生物医药科技有限公司 | 2024-06-20 | — | — | WO | disclosed |
| EP-4365176-A1 | KRAS G12D INHIBITOR AND USE THEREOF | Shanghai de Novo Pharmatech Co., Ltd. (CN) | 2024-05-08 | — | — | EP | disclosed |
| CN-117800976-A | Nitrogen-containing heterocyclic compound, preparation method and application | 上海凌达生物医药有限公司 | 2024-04-02 | — | — | CN | disclosed |
| EP-4291563-A1 | TETRACYCLIC OXAZEPINE COMPOUNDS AND USES THEREOF | Genentech, Inc. (US) | 2023-12-20 | — | — | EP | disclosed |
| CN-116867792-A | Tetraepoxyazepine compound and use thereof | 基因泰克公司 | 2023-10-10 | — | — | CN | disclosed |
| WO-2023274383-A1 | KRAS G12D INHIBITOR AND USE THEREOF | 上海迪诺医药科技有限公司 | 2023-01-05 | — | — | WO | disclosed |
| WO-2023274383-A1 | KRAS G12D INHIBITOR AND USE THEREOF | 上海迪诺医药科技有限公司 | 2023-01-05 | — | — | WO | disclosed |
| CN-115557974-A | KRAS G12D inhibitor and application thereof | 上海迪诺医药科技有限公司 | 2023-01-03 | — | — | CN | disclosed |
| US-20220281893-A1 | TETRACYCLIC OXAZEPINE COMPOUNDS AND USES THEREOF | GENENTECH, INC. (US) | 2022-09-08 | — | — | US | disclosed |
| WO-2022173678-A1 | TETRACYCLIC OXAZEPINE COMPOUNDS AND USES THEREOF | GENENTECH, INC. (US) | 2022-08-18 | — | — | WO | disclosed |