Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SYK | P43405 | 4/20 | 0.50 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.48 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.48 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.48 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.48 |
| ▸ | BRD4 | O60885 | 2/20 | 0.41 |
| ▸ | JAK2 | O60674 | 1/20 | 0.39 |
| ▸ | SCN9A | Q15858 | 2/20 | 0.39 |
| ▸ | NPC1 | O15118 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | RAB9A | P51151 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | TTBK1 | Q5TCY1 | 1/20 | 0.38 |
| ▸ | TTBK2 | Q6IQ55 | 1/20 | 0.38 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.38 |
| ▸ | SCN5A | Q14524 | 1/20 | 0.38 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.37 |
| ▸ | GPR65 | Q8IYL9 | 1/20 | 0.37 |
| ▸ | PTGIR | P43119 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24866862 | 0.80 | HDAC3 (0.48) | HDAC3HDAC1HDAC2HDAC6JAK2 | |
| SCHEMBL18835026 | 0.77 | SYK (0.51) | SYKNPC1MAPTRAB9AKMT2A | |
| SCHEMBL24867198 | 0.75 | HDAC3 (0.49) | HDAC3HDAC1HDAC2HDAC6SCN9A | |
| SCHEMBL24867280 | 0.73 | SYK (0.49) | SYKBRD4SCN9ANPC1MAPT | |
| SCHEMBL24866902 | 0.72 | HDAC3 (0.46) | SYKHDAC3HDAC1HDAC2HDAC6 | |
| SCHEMBL24867272 | 0.72 | SYK (0.60) | SYKNPC1MAPTRAB9AKMT2A | |
| SCHEMBL24867176 | 0.72 | HDAC3 (0.46) | HDAC3HDAC1HDAC2HDAC6KCNH2 | |
| SCHEMBL2723103 | 0.72 | GLA (0.57) | SYKNPC1MAPTRAB9AKMT2A | |
| SCHEMBL24867305 | 0.71 | SYK (0.49) | SYKALDH1A1LMNATP53MAPK1 | |
| SCHEMBL10048417 | 0.71 | SYK (0.48) | SYKNPC1MAPTRAB9AKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023283488-A9 | CDK19-SELECTIVE INHIBITORS, AND METHODS OF USE THEREOF | CZ BIOHUB SF, LLC (US) | 2023-05-25 | — | — | WO | disclosed |
| WO-2023283488-A2 | CDK19-SELECTIVE INHIBITORS, AND METHODS OF USE THEREOF | CHAN ZUCKERBERG BIOHUB, INC. (US) | 2023-01-12 | — | — | WO | disclosed |