Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Oxalic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A4 known ✓ | P31645 | 11/20 | 0.61 |
| ▸ | OPRM1 known ✓ | P35372 | 1/20 | 0.57 |
| ▸ | SLC6A2 | P23975 | 11/20 | 0.61 |
| ▸ | SLC6A3 | Q01959 | 9/20 | 0.61 |
| ▸ | HTR1A | P08908 | 2/20 | 0.57 |
| ▸ | MLNR | O43193 | 1/20 | 0.57 |
| ▸ | CACNA1F | O60840 | 1/20 | 0.57 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.57 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.57 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.57 |
| ▸ | GAA | P10253 | 1/20 | 0.57 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.57 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.57 |
| ▸ | DRD2 | P14416 | 1/20 | 0.57 |
| ▸ | KCNE1 | P15382 | 1/20 | 0.57 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.57 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.57 |
| ▸ | HTR2A | P28223 | 1/20 | 0.57 |
| ▸ | HTR2C | P28335 | 1/20 | 0.57 |
| ▸ | MC4R | P32245 | 1/20 | 0.57 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Oxalic Acid SCHEMBL1535366 | 1.00 | SLC6A2 (0.61) | SLC6A2SLC6A4SLC6A3HTR1AMLNR | |
| SCHEMBL2450624 | 0.93 | SLC6A2 (0.69) | SLC6A2SLC6A4SLC6A3HTR1AMLNR | |
| Maleic Acid SCHEMBL4620953 | 0.93 | SLC6A2 (0.57) | SLC6A2SLC6A4SLC6A3HTR1AMLNR | |
| Cadaverine Tartrate SCHEMBL5807971 | 0.92 | SLC6A2 (0.56) | SLC6A2SLC6A4SLC6A3HTR1AMLNR | |
| Phosphoric Acid SCHEMBL4452410 | 0.91 | SLC6A2 (0.61) | SLC6A2SLC6A4SLC6A3HTR1AMLNR | |
| SCHEMBL4438987 | 0.87 | SLC6A2 (0.52) | SLC6A2SLC6A4SLC6A3HTR1AMLNR | |
| Oxalic Acid SCHEMBL4442947 | 0.84 | SLC6A2 (0.61) | SLC6A2SLC6A4SLC6A3HTR1AMLNR | |
| R-Norduloxetine SCHEMBL3890591 | 0.84 | SLC6A2 (0.86) | SLC6A2SLC6A4SLC6A3HTR1AMLNR | |
| Oxalic Acid SCHEMBL27274794 | 0.83 | KDM4E (0.41) | SLC6A2SLC6A4SLC6A3HTR1AMLNR | |
| Oxalic Acid SCHEMBL27273555 | 0.83 | CACNA2D1 (0.42) | SLC6A2SLC6A4SLC6A3HTR1AMLNR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2376471-A2 | AN IMPROVED PROCESS FOR THE PREPARATION OF DULOXETINE AND SALTS THEREOF | Alembic Limited (IN) | 2011-10-19 | — | — | EP | disclosed |
| WO-2010079404-A2 | AN IMPROVED PROCESS FOR THE PREPARATION OF DULOXETINE AND SALTS THEREOF | ALEMBIC LIMITED (IN) | 2010-07-15 | — | — | WO | disclosed |