Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HCRTR2 | O43614 | 14/20 | 0.43 |
| ▸ | HCRTR1 | O43613 | 13/20 | 0.43 |
| ▸ | TP53 | P04637 | 1/20 | 0.39 |
| ▸ | REN | P00797 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2511884 | 1.00 | HCRTR2 (0.43) | HCRTR2HCRTR1TP53REN | |
| Hydrochloric Acid SCHEMBL2512239 | 0.99 | HCRTR2 (0.42) | HCRTR2HCRTR1TP53REN | |
| SCHEMBL2513353 | 0.94 | HCRTR1 (0.45) | HCRTR2HCRTR1 | |
| Hydrochloric Acid SCHEMBL2533566 | 0.93 | HCRTR1 (0.44) | HCRTR2HCRTR1 | |
| SCHEMBL2509592 | 0.91 | HCRTR2 (0.42) | HCRTR2HCRTR1 | |
| SCHEMBL2486761 | 0.90 | HSD17B10 (0.44) | HCRTR2HCRTR1TP53REN | |
| SCHEMBL2515332 | 0.90 | HSD17B10 (0.44) | HCRTR2HCRTR1TP53REN | |
| Hydrochloric Acid SCHEMBL2536527 | 0.90 | HCRTR2 (0.42) | HCRTR2HCRTR1 | |
| SCHEMBL2534343 | 0.90 | HCRTR2 (0.41) | HCRTR2HCRTR1 | |
| SCHEMBL2510992 | 0.87 | HCRTR1 (0.42) | HCRTR2HCRTR1TP53REN |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2379550-A1 | PIPERIDINE DERIVATIVES USEFUL AS OREXIN ANTAGONISTS | Glaxo Group Limited (GB) | 2011-10-26 | — | — | EP | claimed |
| WO-2010072722-A1 | PIPERIDINE DERIVATIVES USEFUL AS OREXIN ANTAGONISTS | GLAXO GROUP LIMITED (GB) | 2010-07-01 | — | — | WO | claimed |
| EP-2379550-A1 | PIPERIDINE DERIVATIVES USEFUL AS OREXIN ANTAGONISTS | Glaxo Group Limited (GB) | 2011-10-26 | — | — | EP | disclosed |
| WO-2010072722-A1 | PIPERIDINE DERIVATIVES USEFUL AS OREXIN ANTAGONISTS | GLAXO GROUP LIMITED (GB) | 2010-07-01 | — | — | WO | disclosed |