Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK2 | O60674 | 17/20 | 0.47 |
| ▸ | PTK2 | Q05397 | 7/20 | 0.45 |
| ▸ | INSR | P06213 | 4/20 | 0.39 |
| ▸ | ALK | Q9UM73 | 3/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL521354 | 0.92 | JAK2 (0.53) | JAK2PTK2INSRALK | |
| SCHEMBL521985 | 0.92 | JAK2 (0.53) | JAK2PTK2INSRALK | |
| SCHEMBL521353 | 0.92 | JAK2 (0.53) | JAK2PTK2INSRALK | |
| SCHEMBL521566 | 0.90 | JAK2 (0.47) | JAK2PTK2INSRALK | |
| SCHEMBL521565 | 0.90 | JAK2 (0.47) | JAK2PTK2INSRALK | |
| SCHEMBL521806 | 0.90 | JAK2 (0.47) | JAK2PTK2INSRALK | |
| SCHEMBL521713 | 0.78 | JAK2 (0.55) | JAK2PTK2INSRALK | |
| SCHEMBL521714 | 0.78 | JAK2 (0.51) | JAK2PTK2INSRALK | |
| SCHEMBL519670 | 0.76 | JAK2 (0.65) | JAK2PTK2INSRALK | |
| SCHEMBL519671 | 0.75 | JAK2 (0.60) | JAK2PTK2INSRALK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2376491-A1 | PYRROLOTRIAZINES AS ALK AND JAK2 INHIBITORS | Cephalon, Inc. (US) | 2011-10-19 | — | — | EP | claimed |
| WO-2010071885-A1 | PYRROLOTRIAZINES AS ALK AND JAK2 INHIBITORS | CEPHALON, INC. (US) | 2010-06-24 | — | — | WO | claimed |