Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OR51E2 | Q9H255 | 2/20 | 0.46 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.46 |
| ▸ | SLC13A3 | Q8WWT9 | 1/20 | 0.46 |
| ▸ | EGLN1 | Q9GZT9 | 1/20 | 0.46 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.40 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.40 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.40 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.40 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.40 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.40 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.40 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.40 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.40 |
| ▸ | HDAC9 | Q9UKV0 | 1/20 | 0.40 |
| ▸ | HDAC5 | Q9UQL6 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 2/20 | 0.38 |
| ▸ | CES2 | O00748 | 5/20 | 0.38 |
| ▸ | CES1 | P23141 | 5/20 | 0.38 |
| ▸ | HAO1 | Q9UJM8 | 1/20 | 0.37 |
| ▸ | TSHR | P16473 | 3/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10983580 | 0.97 | OR51E2 (0.43) | OR51E2MAPK1SLC13A3EGLN1HDAC3 | |
| SCHEMBL10978027 | 0.97 | OR51E2 (0.43) | OR51E2MAPK1SLC13A3EGLN1HDAC3 | |
| SCHEMBL10984852 | 0.97 | OR51E2 (0.43) | OR51E2MAPK1SLC13A3EGLN1HDAC3 | |
| SCHEMBL10980448 | 0.97 | OR51E2 (0.43) | OR51E2MAPK1SLC13A3EGLN1HDAC3 | |
| SCHEMBL10985970 | 0.97 | OR51E2 (0.43) | OR51E2MAPK1SLC13A3EGLN1HDAC3 | |
| SCHEMBL10979630 | 0.97 | OR51E2 (0.43) | OR51E2MAPK1SLC13A3EGLN1HDAC3 | |
| SCHEMBL10979886 | 0.97 | OR51E2 (0.43) | OR51E2MAPK1SLC13A3EGLN1HDAC3 | |
| SCHEMBL10982138 | 0.97 | OR51E2 (0.43) | OR51E2MAPK1SLC13A3EGLN1HDAC3 | |
| SCHEMBL10982069 | 0.97 | OR51E2 (0.43) | OR51E2MAPK1SLC13A3EGLN1HDAC3 | |
| SCHEMBL10983212 | 0.97 | OR51E2 (0.43) | OR51E2MAPK1SLC13A3EGLN1HDAC3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2376085-A1 | COMPOUNDS AND METHODS OF USE | Genentech, Inc. (US) | 2011-10-19 | — | — | EP | disclosed |
| WO-2010080478-A1 | COMPOUNDS AND METHODS OF USE | GENENTECH, INC. (US) | 2010-07-15 | — | — | WO | disclosed |