Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAP3K11 | Q16584 | 10/20 | 0.46 |
| ▸ | FYN | P06241 | 3/20 | 0.36 |
| ▸ | BRD4 | O60885 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | GLA | P06280 | 1/20 | 0.36 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.36 |
| ▸ | EGFR | P00533 | 1/20 | 0.35 |
| ▸ | IGF1R | P08069 | 1/20 | 0.35 |
| ▸ | SRC | P12931 | 1/20 | 0.35 |
| ▸ | FLT4 | P35916 | 1/20 | 0.35 |
| ▸ | KDR | P35968 | 1/20 | 0.35 |
| ▸ | FLT3 | P36888 | 1/20 | 0.35 |
| ▸ | EPHB4 | P54760 | 1/20 | 0.35 |
| ▸ | TEK | Q02763 | 1/20 | 0.35 |
| ▸ | SYK | P43405 | 2/20 | 0.34 |
| ▸ | KIT | P10721 | 1/20 | 0.33 |
| ▸ | CHEK2 | O96017 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17506430 | 0.82 | BRD4 (0.30) | BRD4 | |
| SCHEMBL720189 | 0.79 | MAP3K11 (0.58) | MAP3K11FYNBRD4KDM4EALDH1A1 | |
| SCHEMBL721588 | 0.78 | MAP3K11 (0.60) | MAP3K11FYNBRD4ALDH1A1HSD17B10 | |
| SCHEMBL720260 | 0.77 | MAP3K11 (0.48) | MAP3K11FYNBRD4ALDH1A1KDR | |
| SCHEMBL27923815 | 0.76 | MAP3K11 (0.46) | MAP3K11FYNBRD4KDM4EALDH1A1 | |
| SCHEMBL722006 | 0.74 | MAP3K11 (0.51) | MAP3K11FYNBRD4KDM4EALDH1A1 | |
| SCHEMBL27923812 | 0.74 | MAP3K11 (0.50) | MAP3K11BRD4KIT | |
| SCHEMBL721984 | 0.73 | MAP3K11 (0.55) | MAP3K11FYNCHEK2 | |
| Formaldehyde SCHEMBL27841166 | 0.72 | MAP3K11 (0.54) | MAP3K11FYNKDM4EALDH1A1GLA | |
| SCHEMBL27905880 | 0.71 | FYN (0.52) | MAP3K11FYNSYK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2576549-A2 | BICYCLIC HETEROARYL KINASE INHIBITORS AND METHODS OF USE | University of Rochester (US) | 2013-04-10 | — | — | EP | disclosed |
| WO-2011149950-A2 | BICYCLIC HETEROARYL KINASE INHIBITORS AND METHODS OF USE | UNIVERSITY OF ROCHESTER (US) | 2011-12-01 | — | — | WO | disclosed |
| EP-2379561-A2 | MLK INHIBITORS AND METHODS OF USE | University Of Rochester (US) | 2011-10-26 | — | — | EP | disclosed |
| WO-2010068483-A2 | MLK INHIBITORS AND METHODS OF USE | UNIVERSITY OF ROCHESTER (US) | 2010-06-17 | — | — | WO | disclosed |