SCHEMBL24879340

SCHEMBL24879340

COCC(Cn1ccc(N)nc1=O)OC

nearest known ligand 0.56

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
FGFR1 P11362 6/20 0.56
SLC22A6 Q4U2R8 1/20 0.55
EP300 Q09472 6/20 0.34
LMNA P02545 3/20 0.33
THRB P10828 1/20 0.33
MTOR P42345 1/20 0.33
MDM2 Q00987 1/20 0.33
NCOA1 Q15788 1/20 0.33
NCOA3 Q9Y6Q9 1/20 0.33
PDE3A Q14432 3/20 0.32
CACNA1F O60840 2/20 0.32
ALB P02768 2/20 0.32
MAPT P10636 2/20 0.32
CACNA1D Q01668 2/20 0.32
CACNA1S Q13698 2/20 0.32
CACNA1C Q13936 2/20 0.32
MCHR1 Q99705 1/20 0.32
PDE4D Q08499 1/20 0.32
SLC29A1 Q99808 1/20 0.32
HPRT1 P00492 1/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7167460 0.89 FGFR1 (0.67) FGFR1SLC22A6EP300LMNATHRB
SCHEMBL14669082 0.82 FGFR1 (0.80) FGFR1SLC22A6HPRT1
SCHEMBL14669196 0.82 FGFR1 (0.80) FGFR1SLC22A6HPRT1
SCHEMBL14669220 0.82 FGFR1 (0.80) FGFR1SLC22A6HPRT1
SCHEMBL13623430 0.82 FGFR1 (0.51) FGFR1SLC22A6EP300LMNATHRB
SCHEMBL16574525 0.81 FGFR1 (0.68) FGFR1SLC22A6EP300HPRT1
SCHEMBL14665357 0.81 FGFR1 (0.67) FGFR1SLC22A6EP300HPRT1
SCHEMBL24879341 0.80 FGFR1 (0.36) FGFR1SLC22A6HPRT1
SCHEMBL14665385 0.79 FGFR1 (0.66) FGFR1SLC22A6EP300HPRT1
SCHEMBL24140140 0.79 FGFR1 (0.68) FGFR1SLC22A6EP300LMNATHRB

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2023283434-A9 AMINOOXY CLICK CHEMISTRY (AOCC): A VERSATILE BIOCONJUGATION APPROACH ALNYLAM PHARMACEUTICALS, INC. (US) 2024-03-28 WO disclosed
WO-2024006953-A2 MONOMERS AND METHODS FOR SYNTHESIS OF MODIFIED OLIGONUCLEOTIDES ALNYLAM PHARMACEUTICALS, INC. (US) 2024-01-04 WO disclosed
WO-2023069495-A1 OLIGONUCLEOTIDES WITH 2'-DEOXY-2'-F-2'-C-METHYL NUCLEOTIDES ALNYLAM PHARMACEUTICALS, INC. (US) 2023-04-27 WO disclosed
WO-2022155418-A9 MODIFIED OLIGONUCLEOTIDES ALNYLAM PHARMACEUTICALS, INC. (US) 2023-03-09 WO disclosed
WO-2023288047-A2 MULTIPLEXING TARGETING LIGANDS THROUGH CLICK CHEMISTRY AT THE ANOMERIC SITE OF SUGARS ALNYLAM PHARMACEUTICALS, INC. (US) 2023-01-19 WO disclosed
WO-2023288045-A2 SIMPLE CHEMICAL APPROACHES TO INTRODUCE 2,6-DIAMINOPURINE AND 2-AMINOADENINE CONJUGATES INTO OLIGONUCLEOTIDES ALNYLAM PHARMACEUTICALS, INC. (US) 2023-01-19 WO disclosed
WO-2023283434-A1 AMINOOXY CLICK CHEMISTRY (AOCC): A VERSATILE BIOCONJUGATION APPROACH ALNYLAM PHARMACEUTICALS, INC. (US) 2023-01-12 WO disclosed