Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAP4K1 | Q92918 | 1/20 | 0.35 |
| ▸ | XPO1 | O14980 | 1/20 | 0.35 |
| ▸ | JAK2 | O60674 | 2/20 | 0.34 |
| ▸ | TRPV1 | Q8NER1 | 4/20 | 0.34 |
| ▸ | MAP3K12 | Q12852 | 1/20 | 0.34 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.33 |
| ▸ | SYK | P43405 | 2/20 | 0.33 |
| ▸ | GRM2 | Q14416 | 1/20 | 0.33 |
| ▸ | JAK1 | P23458 | 1/20 | 0.33 |
| ▸ | TYK2 | P29597 | 1/20 | 0.33 |
| ▸ | JAK3 | P52333 | 1/20 | 0.33 |
| ▸ | TEAD1 | P28347 | 1/20 | 0.33 |
| ▸ | HCRTR1 | O43613 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30114217 | 0.85 | TEAD1 (0.49) | MAP4K1JAK2TRPV1MAP3K12TEAD1 | |
| SCHEMBL24879922 | 0.85 | TEAD1 (0.49) | MAP4K1JAK2TRPV1MAP3K12TEAD1 | |
| SCHEMBL24880103 | 0.81 | FGFR4 (0.35) | TRPV1MAP3K12KCNH2TEAD1 | |
| SCHEMBL24879888 | 0.80 | KCNH2 (0.36) | TRPV1MAP3K12KCNH2TEAD1HCRTR1 | |
| SCHEMBL24880208 | 0.80 | TRPV1 (0.33) | XPO1TRPV1MAP3K12KCNH2TEAD1 | |
| SCHEMBL24879891 | 0.80 | KCNH2 (0.36) | TRPV1MAP3K12KCNH2TEAD1HCRTR1 | |
| SCHEMBL24880379 | 0.78 | TEAD1 (0.35) | JAK2TRPV1MAP3K12KCNH2GRM2 | |
| SCHEMBL24879779 | 0.77 | TEAD1 (0.35) | TRPV1MAP3K12KCNH2GRM2TEAD1 | |
| SCHEMBL24790230 | 0.76 | TEAD1 (0.50) | XPO1TRPV1KCNH2JAK1TYK2 | |
| SCHEMBL24880346 | 0.76 | TEAD1 (0.34) | TRPV1MAP3K12KCNH2GRM2TEAD1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023280254-A1 | TEAD INHIBITOR | 武汉人福创新药物研发中心有限公司 | 2023-01-12 | — | — | WO | disclosed |